The Role of the Pathology Department in the Preanalytical Phase of Molecular Analyses

Overview

Journal Cancer Manag Res

Publisher Dove Medical Press

Specialty Oncology

Date 2018 Apr 27

PMID 29695931

Citations 9

Authors

Sergiu Susman

Ioana Berindan-Neagoe

Bobe Petrushev

Radu Pirlog

Ioan-Stefan Florian

Carmen-Mihaela Mihu

Cristian Berce

Lucian Craciun

Ravnit Grewal

Ciprian Tomuleasa

Affiliations

Soon will be listed here.

Abstract

After introducing the new molecules for the treatment of patients with tumoral pathology, the therapeutical decision will be taken depending on the molecular profile performed upon the harvested tissues. This major modification makes the molecular and morphological analysis an essential part in the clinical management of patients and the pathologist plays an important role in this process. The quality and reproducibility of the results are imperative today and they depend on both the reliability of the molecular techniques and the quality of the tissue we use in the process. Also, the genomics and proteomics techniques, used increasingly often, require high-quality tissues, and pathology laboratories play a very significant role in the management of all phases of this process. In this paper the parameters which must be followed in order to obtain optimal results within the techniques which analyze nucleic acids and proteins were reviewed.

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