Circulating MicroRNAs As Novel Biomarkers for Atherosclerosis

Overview

Journal In Vivo

Specialty Oncology

Date 2018 Apr 27

PMID 29695561

Citations 11

Authors

Seda Gulec Yilmaz

Selim Isbir

Atike Tekeli Kunt

Turgay Isbir

Affiliations

Soon will be listed here.

Abstract

Background/aim: In this study, we determined the expression of selected circulating microRNAs (miRNA) and their potential roles as biomarkers in patients with atherosclerosis and a control group.

Materials And Methods: In order to obtain insight into miRNA expression levels in atherosclerosis, we analyzed miRNA expression levels by real-time polymerase chain reaction (RT-PCR) in case (n=89) and healthy control (n=93) groups. Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of miRNAs.

Results: miRNA221 and miRNA221 expression levels were significantly lower in patients than controls (p=0.011 and p=0.004, respectively). Receiver operator curve analysis demonstrated that expression levels of miRNA221 [area under curve (AUC)=0.623, p=0.0086) and miRNA222 (AUC=0.654, p=0.0006) were significantly different between groups. There were positive correlations between miRNA122a and triglyceride (p=0.046) and very-low-density lipoprotein (p=0.029) levels.

Conclusion: miRNA221 and miRNA222 could be convenient biomarkers for diagnosis of atherosclerosis.

Citing Articles

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The key role of microRNA-766 in the cancer development.

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MiRNA-130a promotes inflammation to accelerate atherosclerosis via the regulation of proliferator-activated receptor γ (PPARγ) expression.

Liu F, Liu Y, Du Y, Li Y Anatol J Cardiol. 2021; 25(9):630-637.

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Solly E, Psaltis P, Bursill C, Tan J Front Pharmacol. 2021; 12:718679.

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