Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2018 Apr 26

PMID 29693979

Citations 3

Authors

H Serpil Akten

Hatice Kilic

Bulent Celik

Gonca Erbas

Zeynep Isikdogan

Haluk Turktas

Nurdan Kokturk

Affiliations

Soon will be listed here.

Abstract

This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients, 19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015. High resolution computerized tomography scans were retrospectively assessed in random order by an experienced observer without knowledge of the bronchoscopic results or lung function tests. According to the radiological staging with HRCT, 2.4% of the patients (n=2) were stage 0, 19.3% (n=16) were stage 1, 72.3% (n=60) were stage 2 and 6.0% (n=5) were stage 3. This study showed that transbronchial lung biopsy showed positive results in 39.7% of the stage I or II sarcoidosis patients who were diagnosed by bronchoscopy. Different high resolution computerized tomography patterns and different scores of involvement did make a difference in the diagnostic accuracy of transbronchial biopsy (p=0.007).

Citing Articles

Prognostic features of sarcoidosis course in a Brazilian cohort.

Castro M, Pereira C, Soares M J Bras Pneumol. 2022; 48(1):e20210366.

PMID: 35137872 PMC: 8836631. DOI: 10.36416/1806-3756/e20210366.

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments.

Jain R, Yadav D, Puranik N, Guleria R, Jin J J Clin Med. 2020; 9(4).

PMID: 32290254 PMC: 7230978. DOI: 10.3390/jcm9041081.

Is Induced Sputum A Useful Noninvasive Tool in the Diagnosis of Pulmonary Sarcoidosis?.

Baha A, Yildirim F, Stark M, Kalkanci A, Fireman E, Kokturk N Turk Thorac J. 2019; 20(4):248-252.

PMID: 31584387 PMC: 6777658. DOI: 10.5152/TurkThoracJ.2018.180147.

References

Costabel U, Ohshimo S, Guzman J . Diagnosis of sarcoidosis. Curr Opin Pulm Med. 2008; 14(5):455-61. DOI: 10.1097/MCP.0b013e3283056a61. View

Tournoy K, Bolly A, Aerts J, Pierard P, De Pauw R, Leduc D . The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis. Eur Respir J. 2009; 35(6):1329-35. DOI: 10.1183/09031936.00111509. View

Lynch 3rd J . Computed tomographic scanning in sarcoidosis. Semin Respir Crit Care Med. 2005; 24(4):393-418. DOI: 10.1055/s-2003-42375. View

Baughman R . Pulmonary sarcoidosis. Clin Chest Med. 2004; 25(3):521-30, vi. DOI: 10.1016/j.ccm.2004.04.006. View

Morales C, Patefield A, Strollo Jr P, Schenk D . Flexible transbronchial needle aspiration in the diagnosis of sarcoidosis. Chest. 1994; 106(3):709-11. DOI: 10.1378/chest.106.3.709. View

Ors F, Gumus S, Aydogan M, Sari S, Verim S, Deniz O . HRCT findings of pulmonary sarcoidosis; relation to pulmonary function tests. Multidiscip Respir Med. 2013; 8(1):8. PMC: 3573933. DOI: 10.1186/2049-6958-8-8. View

Kiter G, Musellim B, Cetinkaya E, Turker H, Kunt Uzaslan A, Yenturk E . Clinical presentations and diagnostic work-up in sarcoidosis: a series of Turkish cases (clinics and diagnosis of sarcoidosis). Tuberk Toraks. 2011; 59(3):248-58. View

Hansell D, Bankier A, MacMahon H, McLoud T, Muller N, Remy J . Fleischner Society: glossary of terms for thoracic imaging. Radiology. 2008; 246(3):697-722. DOI: 10.1148/radiol.2462070712. View

. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by.... Am J Respir Crit Care Med. 1999; 160(2):736-55. DOI: 10.1164/ajrccm.160.2.ats4-99. View

10.

Goyal A, Gupta D, Agarwal R, Bal A, Nijhawan R, Aggarwal A . Value of different bronchoscopic sampling techniques in diagnosis of sarcoidosis: a prospective study of 151 patients. J Bronchology Interv Pulmonol. 2014; 21(3):220-6. DOI: 10.1097/LBR.0000000000000081. View

11.

Chapman J, Mehta A . Bronchoscopy in sarcoidosis: diagnostic and therapeutic interventions. Curr Opin Pulm Med. 2003; 9(5):402-7. DOI: 10.1097/00063198-200309000-00011. View

12.

Torrington K, Shorr A, Parker J . Endobronchial disease and racial differences in pulmonary sarcoidosis. Chest. 1997; 111(3):619-22. DOI: 10.1378/chest.111.3.619. View

13.

von Bartheld M, Dekkers O, Szlubowski A, Eberhardt R, Herth F, In t Veen J . Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial. JAMA. 2013; 309(23):2457-64. DOI: 10.1001/jama.2013.5823. View

14.

Hu L, Chen R, Huang H, Shao C, Wang P, Liu Y . Endobronchial Ultrasound-guided Transbronchial Needle Aspiration versus Standard Bronchoscopic Modalities for Diagnosis of Sarcoidosis: A Meta-analysis. Chin Med J (Engl). 2016; 129(13):1607-15. PMC: 4931269. DOI: 10.4103/0366-6999.184458. View

15.

Navani N, Booth H, Kocjan G, Falzon M, Capitanio A, Brown J . Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis. Respirology. 2011; 16(3):467-72. PMC: 3361303. DOI: 10.1111/j.1440-1843.2011.01933.x. View

16.

Descombes E, Gardiol D, Leuenberger P . Transbronchial lung biopsy: an analysis of 530 cases with reference to the number of samples. Monaldi Arch Chest Dis. 1997; 52(4):324-9. View

17.

de Boer S, Milne D, Zeng I, Wilsher M . Does CT scanning predict the likelihood of a positive transbronchial biopsy in sarcoidosis?. Thorax. 2009; 64(5):436-9. DOI: 10.1136/thx.2008.105031. View

18.

Leonard C, Tormey V, OKeane C, Burke C . Bronchoscopic diagnosis of sarcoidosis. Eur Respir J. 1998; 10(12):2722-4. DOI: 10.1183/09031936.97.10122722. View