Cooperativity Principles in Self-Assembled Nanomedicine

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2018 Apr 26

PMID 29693377

Citations 40

Authors

Yang Li

Yiguang Wang

Gang Huang

Jinming Gao

Affiliations

Soon will be listed here.

Abstract

Nanomedicine is a discipline that applies nanoscience and nanotechnology principles to the prevention, diagnosis, and treatment of human diseases. Self-assembly of molecular components is becoming a common strategy in the design and syntheses of nanomaterials for biomedical applications. In both natural and synthetic self-assembled nanostructures, molecular cooperativity is emerging as an important hallmark. In many cases, interplay of many types of noncovalent interactions leads to dynamic nanosystems with emergent properties where the whole is bigger than the sum of the parts. In this review, we provide a comprehensive analysis of the cooperativity principles in multiple self-assembled nanostructures. We discuss the molecular origin and quantitative modeling of cooperative behaviors. In selected systems, we describe the examples on how to leverage molecular cooperativity to design nanomedicine with improved diagnostic precision and therapeutic efficacy in medicine.

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