Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

Overview

Journal Front Pharmacol

Date 2018 Apr 26

PMID 29692728

Citations 21

Authors

Agatha Oliveira-Giacomelli

Yahaira Naaldijk

Laura Sarda-Arroyo

Maria C B Goncalves

Juliana Correa-Velloso

Micheli M Pillat

Hellio D N de Souza

Henning Ulrich

Affiliations

Soon will be listed here.

Abstract

Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system. In neurological disorders with associated motor symptoms, including Parkinson's disease (PD), motor neuron diseases (MND), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington's Disease (HD), restless leg syndrome (RLS), and ataxias, alterations in purinergic receptor expression and activity have been noted, indicating a potential role for this system in disease etiology and progression. In neurodegenerative conditions, neural cell death provokes extensive ATP release and alters calcium signaling through purinergic receptor modulation. Consequently, neuroinflammatory responses, excitotoxicity and apoptosis are directly or indirectly induced. This review analyzes currently available data, which suggests involvement of the purinergic system in neuro-associated motor dysfunctions and underlying mechanisms. Possible targets for pharmacological interventions are also discussed.

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References

Apolloni S, Parisi C, Pesaresi M, Rossi S, Carri M, Cozzolino M . The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis. J Immunol. 2013; 190(10):5187-95. DOI: 10.4049/jimmunol.1203262. View

Verschueren A . Motor neuropathies and lower motor neuron syndromes. Rev Neurol (Paris). 2017; 173(5):320-325. DOI: 10.1016/j.neurol.2017.03.018. View

Mayne M, Shepel P, Jiang Y, Geiger J, Power C . Dysregulation of adenosine A1 receptor-mediated cytokine expression in peripheral blood mononuclear cells from multiple sclerosis patients. Ann Neurol. 1999; 45(5):633-9. DOI: 10.1002/1531-8249(199905)45:5<633::aid-ana12>3.0.co;2-x. View

Popoli P, Pintor A, Domenici M, Frank C, Tebano M, Pezzola A . Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. J Neurosci. 2002; 22(5):1967-75. PMC: 6758877. View

Jung C, Higgins C, Xu Z . Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis. J Neurochem. 2002; 83(3):535-45. DOI: 10.1046/j.1471-4159.2002.01112.x. View

Liu Y, Lee L, Lai H, Chern Y . Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis. FEBS Lett. 2015; 589(4):432-9. DOI: 10.1016/j.febslet.2014.12.029. View

Song X, Xu X, Zhu J, Guo Z, Li J, He C . Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Purinergic Signal. 2015; 11(2):203-13. PMC: 4425717. DOI: 10.1007/s11302-015-9445-8. View

Burnstock G . The therapeutic potential of purinergic signalling. Biochem Pharmacol. 2017; 151:157-165. DOI: 10.1016/j.bcp.2017.07.016. View

Simonin C, Duru C, Salleron J, Hincker P, Charles P, Delval A . Association between caffeine intake and age at onset in Huntington's disease. Neurobiol Dis. 2013; 58:179-82. DOI: 10.1016/j.nbd.2013.05.013. View

10.

Mojsilovic-Petrovic J, Jeong G, Crocker A, Arneja A, David S, Russell D . Protecting motor neurons from toxic insult by antagonism of adenosine A2a and Trk receptors. J Neurosci. 2006; 26(36):9250-63. PMC: 6674510. DOI: 10.1523/JNEUROSCI.1856-06.2006. View

11.

Burnstock G, Campbell G, Satchell D, Smythe A . Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol. 1970; 40(4):668-88. PMC: 1702901. DOI: 10.1111/j.1476-5381.1970.tb10646.x. View

12.

Lefebvre S, Burlet P, Liu Q, Bertrandy S, Clermont O, Munnich A . Correlation between severity and SMN protein level in spinal muscular atrophy. Nat Genet. 1997; 16(3):265-9. DOI: 10.1038/ng0797-265. View

13.

Moreno E, Chiarlone A, Medrano M, Puigdellivol M, Bibic L, Howell L . Singular Location and Signaling Profile of Adenosine A-Cannabinoid CB Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology. 2017; 43(5):964-977. PMC: 5854787. DOI: 10.1038/npp.2017.12. View

14.

Popat R, Van Den Eeden S, Tanner C, Kamel F, Umbach D, Marder K . Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease. Eur J Neurol. 2011; 18(5):756-65. PMC: 3556904. DOI: 10.1111/j.1468-1331.2011.03353.x. View

15.

Cheffer A, Castillo A, Correa-Velloso J, Goncalves M, Naaldijk Y, Nascimento I . Purinergic system in psychiatric diseases. Mol Psychiatry. 2017; 23(1):94-106. DOI: 10.1038/mp.2017.188. View

16.

Kazemi M, Raoofi Mohseni S, Hojjat-Farsangi M, Anvari E, Ghalamfarsa G, Mohammadi H . Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer. J Cell Physiol. 2017; 233(3):2032-2057. DOI: 10.1002/jcp.25873. View

17.

Chiu F, Lin J, Chuang C, Chien T, Chen C, Chen K . Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs. Hum Mol Genet. 2015; 24(21):6066-79. DOI: 10.1093/hmg/ddv318. View

18.

Faria R, Freitas H, Reis R . P2X7 receptor large pore signaling in avian Müller glial cells. J Bioenerg Biomembr. 2017; 49(3):215-229. DOI: 10.1007/s10863-017-9717-9. View

19.

Fondell E, OReilly E, Fitzgerald K, Falcone G, Kolonel L, Park Y . Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies. Amyotroph Lateral Scler Frontotemporal Degener. 2015; 16(5-6):366-71. PMC: 4589421. DOI: 10.3109/21678421.2015.1020813. View

20.

Goncalves N, Simoes A, Prediger R, Hirai H, Cunha R, de Almeida L . Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia. Ann Neurol. 2016; 81(3):407-418. DOI: 10.1002/ana.24867. View