Improved Osseointegration Properties of Hierarchical Microtopographic/nanotopographic Coatings Fabricated on Titanium Implants

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2018 Apr 26

PMID 29692612

Citations 8

Authors

Elena G Zemtsova

Natalia M Yudintceva

Pavel E Morozov

Ruslan Z Valiev

Vladimir M Smirnov

Maxim A Shevtsov

Affiliations

Soon will be listed here.

Abstract

Background: Titanium (Ti) implants are extensively used in reconstructive surgery and orthopedics. However, the intrinsic inertness of untreated Ti implants usually results in insufficient osseointegration. In order to improve the osteoconductivity properties of the implants, they are coated with hierarchical microtopographic/nanotopographic coatings employing the method of molecular layering of atomic layer deposition (ML-ALD).

Results: The analysis of the fabricated nanostructured relief employing scanning electron microscopy, atomic force microscopy, and electron spectroscopy for chemical analysis clearly demonstrated the formation of the nanotopographic (<100 nm) and microtopographic (0.1-0.5 μm) titano-organic structures on the surface of the nanograined Ti implants. Subsequent coincubation of the MC3T3-E1 mouse osteoblasts on the microtopographic/nanotopographic surface of the implants resulted in enhanced osteogenic cell differentiation (the production of alkaline phosphatase, osteopontin, and osteocalcin). In vivo assessment of the osseointegrative properties of the microtopographically/nanotopographically coated implants in a model of below-knee amputation in New Zealand rabbits demonstrated enhanced new bone formation in the zone of the bone-implant contact (as measured by X-ray study) and increased osseointegration strength (removal torque measurements).

Conclusion: The fabrication of the hierarchical microtopographic/nanotopographic coatings on the nanograined Ti implants significantly improves the osseointegrative properties of the intraosseous Ti implants. This effect could be employed in both translational and clinical studies in orthopedic and reconstructive surgery.

Citing Articles

Comparison In Vitro Study on the Interface between Skin and Bone Cell Cultures and Microporous Titanium Samples Manufactured with 3D Printing Technology Versus Sintered Samples.

Shevtsov M, Pitkin E, Combs S, Meulen G, Preucil C, Pitkin M Nanomaterials (Basel). 2024; 14(18).

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Nanoporous Titanium Implant Surface Accelerates Osteogenesis via the Piezo1/Acetyl-CoA/β-Catenin Pathway.

Zhang Q, Pan R, Wang H, Wang J, Lu S, Zhang M Nano Lett. 2024; 24(27):8257-8267.

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Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells signal transducer and activator of transcription 3 pathway.

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Creation of a Composite Bioactive Coating with Antibacterial Effect Promising for Bone Implantation.

Zemtsova E, Kozlova L, Yudintceva N, Sokolova D, Arbenin A, Ponomareva A Molecules. 2023; 28(3).

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Osteoblast Attachment on Titanium Coated with Hydroxyapatite by Atomic Layer Deposition.

Kylmaoja E, Holopainen J, Abushahba F, Ritala M, Tuukkanen J Biomolecules. 2022; 12(5).

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