Medication-related Risk Factors Associated with Health-related Quality of Life Among Community-dwelling Elderly in China

Overview

Journal Patient Prefer Adherence

Date 2018 Apr 26

PMID 29692604

Citations 7

Authors

Sha Zhang

Long Meng

Feng Qiu

Jia-Dan Yang

Shusen Sun

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have demonstrated that medication adherence has an impact on health-related quality of life (HRQoL). However, other medication-related factors that may influence HRQoL have not been extensively studied, especially factors based on the Medication-Risk Questionnaire (MRQ), and such studies are mostly done in Western countries. Our objective was to explore risk factors associated with HRQoL among community-dwelling elderly with chronic diseases in mainland China, especially the medication-related risk factors regarding MRQ.

Methods: The study was conducted in a community health service center through surveys to eligible patients. The main outcomes of HRQoL were assessed by the EuroQol-5D (EQ-5D) scale and EQ-visual analog scale (EQ-VAS). Medication-related risk factors according to MRQ associated with HRQoL were identified using a multiple linear regression.

Results: A total of 311 patients were analyzed, averaging 71.19±5.33 years, and 68.8% were female. The mean EQ-5D index was 0.72±0.09, and the mean EQ-VAS score was 71.37±11.97. The most prevalent problem was pain/discomfort, and 90.0% believed that they could take care of themselves without any problems. Sex, age, educational level, frailty, function status, and certain medication-related factors regarding MRQ were found to be significant factors impacting the HRQoL. A multivariate analysis showed that MRQ factors of polypharmacy, multimorbidity, feeling difficultly with taking medicines as prescribed, and taking medicines with narrow therapeutic index had negative impacts on the quality of life.

Conclusion: Patient's internal characteristics and medication-related risk factors according to MRQ were associated with quality of life. The results of the MRQ is an indicator of quality of life that can identify patients who need interventions.

Citing Articles

Implementation of a value-based approach for older people who have suffered an acute myocardial infarction: study protocol.

Juraga D, Rukavina T, Marinovic Glavic M, Bilajac L, Racz A, Bally E Front Public Health. 2025; 12():1518469.

PMID: 39830183 PMC: 11738907. DOI: 10.3389/fpubh.2024.1518469.

Impacts of chronic diseases and multimorbidity on health-related quality of life among community-dwelling elderly individuals in economically developed China: evidence from cross-sectional survey across three urban centers.

Liang X, Wei H, Mo H, Yang G, Wan L, Dong H Health Qual Life Outcomes. 2024; 22(1):91.

PMID: 39462427 PMC: 11515108. DOI: 10.1186/s12955-024-02309-z.

Implementation of a Comprehensive and Personalised Approach for Older People with Psychosocial Frailty in Valencia (Spain): Study Protocol for a Pre-Post Controlled Trial.

Fernandez-Salido M, Alhambra-Borras T, Garces-Ferrer J Int J Environ Res Public Health. 2024; 21(6).

PMID: 38928961 PMC: 11203706. DOI: 10.3390/ijerph21060715.

Factors associated with health-related quality of life among community-dwelling older adults: the APPCARE study.

Bally E, Korenhof S, Ye L, van Grieken A, Tan S, Mattace-Raso F Sci Rep. 2024; 14(1):14351.

PMID: 38906882 PMC: 11192871. DOI: 10.1038/s41598-024-64539-x.

Quality of life in patients with fibromyalgia: Contributions of disease symptoms, lifestyle and multi-medication.

Fernandez-Feijoo F, Samartin-Veiga N, Carrillo-de-la-Pena M Front Psychol. 2022; 13:924405.

PMID: 36262444 PMC: 9574370. DOI: 10.3389/fpsyg.2022.924405.

References

Rabin R, de Charro F . EQ-5D: a measure of health status from the EuroQol Group. Ann Med. 2001; 33(5):337-43. DOI: 10.3109/07853890109002087. View

Chen H, Rosenzweig E, Gotzkowsky S, Arneson C, Nelsen A, Bourge R . Treatment satisfaction is associated with improved quality of life in patients treated with inhaled treprostinil for pulmonary arterial hypertension. Health Qual Life Outcomes. 2013; 11:31. PMC: 3610124. DOI: 10.1186/1477-7525-11-31. View

Lee C, George J, Elliott R, Stewart K . Prevalence of medication-related risk factors among retirement village residents: a cross-sectional survey. Age Ageing. 2010; 39(5):581-7. DOI: 10.1093/ageing/afq079. View

Williams A, Manias E, Walker R . Adherence to multiple, prescribed medications in diabetic kidney disease: A qualitative study of consumers' and health professionals' perspectives. Int J Nurs Stud. 2008; 45(12):1742-56. DOI: 10.1016/j.ijnurstu.2008.07.002. View

Lim L, McStea M, Chung W, Azmi N, Abdul Aziz S, Alwi S . Prevalence, risk factors and health outcomes associated with polypharmacy among urban community-dwelling older adults in multi-ethnic Malaysia. PLoS One. 2017; 12(3):e0173466. PMC: 5342241. DOI: 10.1371/journal.pone.0173466. View

Barenholtz Levy H . Self-administered medication-risk questionnaire in an elderly population. Ann Pharmacother. 2003; 37(7-8):982-7. DOI: 10.1345/aph.1C305. View

Al-Jabi S, Zyoud S, Sweileh W, Wildali A, Saleem H, Aysa H . Relationship of treatment satisfaction to health-related quality of life: findings from a cross-sectional survey among hypertensive patients in Palestine. Health Expect. 2014; 18(6):3336-48. PMC: 5810714. DOI: 10.1111/hex.12324. View

Tayebati S, Nittari G, Mahdi S, Ioannidis N, Sibilio F, Amenta F . Identification of World Health Organisation ship's medicine chest contents by Anatomical Therapeutic Chemical (ATC) classification codes. Int Marit Health. 2017; 68(1):39-45. DOI: 10.5603/IMH.2017.0007. View

Kastien-Hilka T, Rosenkranz B, Bennett B, Sinanovic E, Schwenkglenks M . How to Evaluate Health-Related Quality of Life and Its Association with Medication Adherence in Pulmonary Tuberculosis - Designing a Prospective Observational Study in South Africa. Front Pharmacol. 2016; 7:125. PMC: 4886690. DOI: 10.3389/fphar.2016.00125. View

10.

Wang H, Kindig D, Mullahy J . Variation in Chinese population health related quality of life: results from a EuroQol study in Beijing, China. Qual Life Res. 2005; 14(1):119-32. DOI: 10.1007/s11136-004-0612-6. View

11.

Eton D, Oliveira D, Egginton J, Ridgeway J, Odell L, May C . Building a measurement framework of burden of treatment in complex patients with chronic conditions: a qualitative study. Patient Relat Outcome Meas. 2012; 3:39-49. PMC: 3506008. DOI: 10.2147/PROM.S34681. View

12.

Tsuchiya A, Ikeda S, Ikegami N, Nishimura S, Sakai I, Fukuda T . Estimating an EQ-5D population value set: the case of Japan. Health Econ. 2002; 11(4):341-53. DOI: 10.1002/hec.673. View

13.

Fang H, Farooq U, Wang D, Yu F, Younus M, Guo X . Reliability and validity of the EQ-5D-3L for Kashin-Beck disease in China. Springerplus. 2016; 5(1):1924. PMC: 5099307. DOI: 10.1186/s40064-016-3613-3. View

14.

Makowsky M, Cave A, Simpson S . Feasibility of a self-administered survey to identify primary care patients at risk of medication-related problems. J Multidiscip Healthc. 2014; 7:123-7. PMC: 3937182. DOI: 10.2147/JMDH.S46910. View

15.

Li W, Cheng Y, Yu X . [Observation on therapeutic effect of acupuncture combined with medicine on mild cognition disorders in patients with post-stroke]. Zhongguo Zhen Jiu. 2012; 32(1):3-7. View

16.

Hall N, Rubin G, Hungin A, Dougall A . Medication beliefs among patients with inflammatory bowel disease who report low quality of life: a qualitative study. BMC Gastroenterol. 2007; 7:20. PMC: 1896170. DOI: 10.1186/1471-230X-7-20. View

17.

McCaffrey N, Kaambwa B, Currow D, Ratcliffe J . Health-related quality of life measured using the EQ-5D-5L: South Australian population norms. Health Qual Life Outcomes. 2016; 14(1):133. PMC: 5028927. DOI: 10.1186/s12955-016-0537-0. View

18.

Saleh F, Mumu S, Ara F, Hafez M, Ali L . Non-adherence to self-care practices & medication and health related quality of life among patients with type 2 diabetes: a cross-sectional study. BMC Public Health. 2014; 14:431. PMC: 4019601. DOI: 10.1186/1471-2458-14-431. View

19.

Delafuente J . Pharmacokinetic and pharmacodynamic alterations in the geriatric patient. Consult Pharm. 2008; 23(4):324-34. DOI: 10.4140/tcp.n.2008.324. View

20.

Ostir G, Eschbach K, Markides K, Goodwin J . Neighbourhood composition and depressive symptoms among older Mexican Americans. J Epidemiol Community Health. 2003; 57(12):987-92. PMC: 1732342. DOI: 10.1136/jech.57.12.987. View