Cardiac Progenitor Cells: The Matrix Has You

Overview

Journal Stem Cells Transl Med

Publisher Oxford University Press

Specialties Cell Biology
Pharmacology

Date 2018 Apr 25

PMID 29688622

Citations 8

Authors

Clotilde Castaldo

Isotta Chimenti

Affiliations

Soon will be listed here.

Abstract

Components of the cardiac extracellular matrix (ECM) are synthesized by residing cells and are continuously remodeled by them. Conversely, residing cells (including primitive cells) receive constant biochemical and mechanical signals from the ECM that modulate their biology. The pathological progression of heart failure affects all residing cells, inevitably causing profound changes in ECM composition and architecture that, in turn, impact on cell phenotypes. Any regenerative medicine approach must aim at sustaining microenvironment conditions that favor cardiogenic commitment of therapeutic cells and minimize pro-fibrotic signals, while conversely boosting the capacity of therapeutic cells to counteract adverse remodeling of the ECM. In this Perspective article, we discuss multiple issues about the features of an optimal scaffold for supporting cardiac tissue engineering strategies with cardiac progenitor cells, and, conversely, about the possible antifibrotic mechanisms induced by cell therapy. Stem Cells Translational Medicine 2018;7:506-510.

Citing Articles

Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights.

Razavi Z, Farokhi S, Mahmoudvand G, Karimi-Rouzbahani A, Farasati-Far B, Tahmasebi-Ghorabi S Front Cell Dev Biol. 2024; 12:1472103.

PMID: 39726717 PMC: 11669526. DOI: 10.3389/fcell.2024.1472103.

Decellularized diseased tissues: current state-of-the-art and future directions.

Li X, Shan J, Chen X, Cui H, Wen G, Yu Y MedComm (2020). 2023; 4(6):e399.

PMID: 38020712 PMC: 10661834. DOI: 10.1002/mco2.399.

Human Cardiac Progenitor Cell-Derived Extracellular Vesicles Exhibit Promising Potential for Supporting Cardiac Repair .

Romano V, Belviso I, Sacco A, Cozzolino D, Nurzynska D, Amarelli C Front Physiol. 2022; 13:879046.

PMID: 35669580 PMC: 9163838. DOI: 10.3389/fphys.2022.879046.

The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells.

Belviso I, Angelini F, Di Meglio F, Picchio V, Sacco A, Nocella C Int J Mol Sci. 2020; 21(21).

PMID: 33114386 PMC: 7662394. DOI: 10.3390/ijms21217903.

Building an Artificial Cardiac Microenvironment: A Focus on the Extracellular Matrix.

Pagliarosi O, Picchio V, Chimenti I, Messina E, Gaetani R Front Cell Dev Biol. 2020; 8:559032.

PMID: 33015056 PMC: 7500153. DOI: 10.3389/fcell.2020.559032.

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