LncRNA NBAT-1 is Down-regulated in Lung Cancer and Influences Cell Proliferation, Apoptosis and Cell Cycle

Overview

Journal Eur Rev Med Pharmacol Sci

Specialties General Medicine
Pharmacology
Toxicology

Date 2018 Apr 25

PMID 29687849

Citations 16

Authors

T Lei

Z-Y Lv

J-F Fu

Z Wang

Z Fan

Y Wang

Affiliations

Soon will be listed here.

Abstract

Objective: To explore the expression and role of lncRNA NBAT-1 in lung cancer.

Patients And Methods: LncRNA NBAT-1 expression in lung cancer tissues and adjacent areas was detected via reverse transcriptase-polymerase chain reaction (RT-PCR). RAC1 protein was analyzed via Western blotting assay. Cell counting kit-8 (CCK-8) and flow cytometry were used to evaluate cell proliferation and apoptosis as well as cell cycle.

Results: The expression level of lncRNA NBAT-1 in cancer specimen was remarkably lower than that in adjacent areas. Furthermore, the low expression of lncRNA NBAT-1 had a significant correlation with patient's tumor size, differentiation degree of tumor cells and lymph node metastasis. The overexpression of lncRNA NBAT-1 could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1.

Conclusions: The low expression of lncRNA NBAT-1 is involved in the progression of lung cancer.

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Li C, Li X J Healthc Eng. 2022; 2022:9121554.

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