Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2018 Apr 24

PMID 29682562

Citations 43

Authors

Saeed S Banawas

Affiliations

Soon will be listed here.

Abstract

is the most prevalent causative pathogen of healthcare-associated diarrhea. Notably, over the past 10 years, the number of outbreaks has increased with the rate of morbidity and mortality. The occurrence and spread of strains that are resistant to multiple antimicrobial drugs complicate prevention as well as potential treatment options. Most isolates are still susceptible to metronidazole and vancomycin. Incidences of resistance to other antimicrobial drugs have also been reported. Most of the antibiotics correlated with infection (CDI), such as ampicillin, amoxicillin, cephalosporins, clindamycin, and fluoroquinolones, continue to be associated with the highest risk for CDI. Still, the detailed mechanism of resistance to metronidazole or vancomycin is not clear. Alternation in the target sites of the antibiotics is the main mechanism of erythromycin, fluoroquinolone, and rifamycin resistance in In this review, different antimicrobial agents are discussed and resistance patterns and their mechanism of survival are summarized.

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