Polymorphisms of Antioxidant Genes As a Target for Diabetes Management

Overview

Journal Int J Mol Cell Med

Specialty Genetics

Date 2018 Apr 24

PMID 29682485

Citations 13

Authors

Ozra Tabatabaei-Malazy

Mehrnoosh Khodaeian

Fatemeh Bitarafan

Bagher Larijani

Mahsa M Amoli

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) is one of the most important health problems with increasing prevalence worldwide. Oxidative stress, a result of imbalance between reactive oxygen species (ROS) generation and antioxidant defense mechanisms has been demonstrated as the main pathology in DM. Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including the polyol pathway, advanced glycation end- products formation, activation of protein kinase C isoforms, and the hexosamine pathways. In the development of type 2 DM (T2DM) and its complications, genetic and environmental factors play important roles. Therefore, the aim of this review was to focus on the assessment of single-nucleotide polymorphisms within antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, nitric oxide synthase, and NAD(P)H oxidase and their association with T2DM. The results would be helpful in understanding the mechanisms involved in pathogenesis of disease besides discovering new treatment approaches in management of DM.

Citing Articles

Genetic research in Immunogenetics Group of Endocrinology and Metabolism Research Institute.

Asgarbeik S, Amoli M, Vahidi A, Klashami Z J Diabetes Metab Disord. 2024; 23(2):1553-1561.

PMID: 39610527 PMC: 11599698. DOI: 10.1007/s40200-021-00753-y.

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.

Sultan S, Alharbi M, Alrayes N, Makki N, Faruqui H, Basuni L Endocrinol Diabetes Metab. 2023; 6(6):e449.

PMID: 37698290 PMC: 10638619. DOI: 10.1002/edm2.449.

Polygenic Variants Linked to Oxidative Stress and the Antioxidant System Are Associated with Type 2 Diabetes Risk and Interact with Lifestyle Factors.

Choi Y, Kwon H, Park S Antioxidants (Basel). 2023; 12(6).

PMID: 37372010 PMC: 10295348. DOI: 10.3390/antiox12061280.

The (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk.

Pavlovic D, Ristic S, Djukanovic L, Matic M, Kovacevic M, Pljesa-Ercegovac M Medicina (Kaunas). 2023; 59(1).

PMID: 36676788 PMC: 9865841. DOI: 10.3390/medicina59010164.

Glutathione S-Transferase P1 Genetic Variant's Influence on the HbA1c Level in Type Two Diabetic Patients.

Orlewska K, Klusek J, Gluszek S, Klusek J, Witczak B, Wawszczak M Int J Environ Res Public Health. 2023; 20(2).

PMID: 36674274 PMC: 9859603. DOI: 10.3390/ijerph20021520.

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