Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Nasopharyngeal Carcinoma Patients After Comprehensive Therapy

Overview

Journal Contrast Media Mol Imaging

Specialty Radiology

Date 2018 Apr 24

PMID 29681779

Citations 1

Authors

Yueli Tian

Khamis Hassan Bakari

Shanshan Liao

Xiaotian Xia

Xun Sun

Chunxia Qin

Yongxue Zhang

Xiaoli Lan

Affiliations

Soon will be listed here.

Abstract

Objective: We assessed the prognostic value of standardized uptake value (SUV) and volume-based methods including whole-body metabolic tumor volume (WBMTV) and whole-body total lesion glycolysis (WBTLG) using F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) of patients with nasopharyngeal carcinoma (NPC) after therapy.

Methods: A total of 221 posttherapy NPC cases were enrolled, all of whom had undergone PET/CT scanning and follow-up in this retrospective study. The diagnostic results of PET/CT were analyzed and compared with histopathological diagnosis or clinical follow-up. Receiver operator characteristic curves, the Kaplan-Meier method, and the log-rank test were used to assess the optimal cutoff values for WBMTV and WBTLG to identify independent predictors of survival.

Results: The detection rates of the threshold SUV were 2.5, 20%, and 40%, and SUV background methods were 65.6% (378/576), 80.2% (462/576), 71.5% (412/576), and 90.4% (521/576), respectively ( < 0.005). Patients with a WBMTV < 8.10 and/or a WBTLG < 35.58 had significantly better 5-year overall survival than those above the cutoffs (90.7% versus 51.2%, < 0.001; 91.7% versus 50.4%, < 0.001), respectively. Multivariate Cox regression modeling showed both WBTLG (RR, 1.002; = 0.004) and age (RR, 1.046; = 0.006) could be used to predict overall survival. WBTLG (RR, 1.003; < 0.001) may have predictive relevance in estimating disease-free survival.

Conclusions: SUV volume-based threshold background methodology had a significantly higher detection rate for metastatic lesions. WBTLG could be used as an independent prognostic indicator for posttherapy NPC.

Citing Articles

Establishment and validation of a nomogram with intratumoral heterogeneity derived from F-FDG PET/CT for predicting individual conditional risk of 5-year recurrence before initial treatment of nasopharyngeal carcinoma.

Gu B, Zhang J, Ma G, Song S, Shi L, Zhang Y BMC Cancer. 2020; 20(1):37.

PMID: 31941465 PMC: 6964088. DOI: 10.1186/s12885-020-6520-5.

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