Non-O Blood Group and Outcomes of in Vitro Fertilization

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2018 Apr 22

PMID 29679182

Citations 5

Authors

M Di Nisio

A Ponzano

G M Tiboni

M D Guglielmi

A W S Rutjes

E Porreca

Affiliations

Soon will be listed here.

Abstract

Purpose: Retrospective and cross-sectional studies suggested that non-O blood group may be associated with failures of in vitro fertilization (IVF), but data remain controversial. The aim of this observational cohort study was to prospectively evaluate the effect of non-O blood type on clinical outcomes of IVF.

Methods: Women < 40 years who underwent IVF and had ABO blood type recorded as part of the routine workup were eligible. The primary study outcome was live birth. Secondary outcomes included spontaneous abortion, positive pregnancy test, and clinical pregnancy.

Results: A total of 497 women with a mean age of 34.6 (standard deviation 3.2) years were included. The mean number of embryos transferred was 2.3 (standard deviation 0.6). The most common ABO blood types were O (n = 213, 42.9%) and A (n = 203, 40.8%), while 63 (12.7%) and 18 (3.6%) women had the B and AB blood types, respectively. Differences in live birth (21.8 vs. 24.3%, odds ratio [OR] 1.17; 95% confidence intervals [CI], 0.76 to 1.78), positive pregnancy test (37.9 vs. 36.6%, OR 0.96; 95% CI, 0.66 to 1.38), clinical pregnancy (35.1 vs. 33.8%, OR 0.95; 95% CI, 0.66 to 1.39), and spontaneous abortion (12.3 vs. 9.2%, OR 0.72; 95% CI, 0.41 to 1.29) between women with O and non-O blood type were not statistically significant.

Conclusions: In a prospective cohort study, we confirmed the lack of a significant association between non-O blood type and clinical outcomes of IVF. Further studies are needed to clarify whether non-O blood group has any prognostic relevance in women undergoing IVF.

Citing Articles

Association of ABO blood groups with ovarian reserve: a retrospective cohort study in Chinese Han women younger than 40 years with infertility.

Sun X, Sun C, Meng M, Liu L J Ovarian Res. 2022; 15(1):132.

PMID: 36539903 PMC: 9769009. DOI: 10.1186/s13048-022-01075-0.

Parent Joint AB Blood Group Is Associated With Clinical Outcomes of Fertilization and Intracytoplasmic Sperm Injection Treatment in Chinese Women.

Bao X, Zhao F, Shi H, Bu Z, Liang Y, Sun Y Front Med (Lausanne). 2022; 9:813781.

PMID: 35602516 PMC: 9115895. DOI: 10.3389/fmed.2022.813781.

Patient engagement in fertility research: bench research, ethics, and social justice.

Fleming P, Swygert M, Hasenkamp C, Sterling J, Cartee G, Russ-Sellers R Res Involv Engagem. 2021; 7(1):29.

PMID: 33980313 PMC: 8115861. DOI: 10.1186/s40900-021-00278-x.

Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses.

Zhao J, Yao Z, Hao J, Xu B, Wang Y, Li Y Reprod Biol Endocrinol. 2021; 19(1):20.

PMID: 33549121 PMC: 7866457. DOI: 10.1186/s12958-020-00685-x.

Effects of Obesity and Thrombophilia on the Risk of Abortion in Women Undergoing Fertilization.

Candeloro M, Di Nisio M, Ponzano A, Tiboni G, Potere N, Tana M Front Endocrinol (Lausanne). 2021; 11:594867.

PMID: 33424770 PMC: 7786836. DOI: 10.3389/fendo.2020.594867.

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