Significance of Aquaporins' Expression in the Prognosis of Gastric Cancer

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Apr 22

PMID 29678898

Citations 21

Authors

Saroj Thapa

Mandika Chetry

Kaiyu Huang

Yangpei Peng

Jinsheng Wang

Jiaoni Wang

Yingying Zhou

Yigen Shen

Yangjing Xue

Kangting Ji

Affiliations

Soon will be listed here.

Abstract

Gastric carcinoma is one of the most lethal malignancy at present with leading cause of cancer-related deaths worldwide. Aquaporins (AQPs) are a family of small, integral membrane proteins, which have been evidenced to play a crucial role in cell migration and proliferation of different cancer cells including gastric cancers. However, the aberrant expression of specific AQPs and its correlation to detect predictive and prognostic significance in gastric cancer remains elusive. In the present study, we comprehensively explored immunohistochemistry based map of protein expression profiles in normal tissues, cancer and cell lines from publicly available Human Protein Atlas (HPA) database. Moreover, to improve our understanding of general gastric biology and guide to find novel predictive prognostic gastric cancer biomarker, we also retrieved 'The Kaplan-Meier plotter' (KM plotter) online database with specific mRNA to overall survival (OS) in different clinicopathological features. We revealed that ubiquitous expression of AQPs protein can be effective tools to generate gastric cancer biomarker. Furthermore, high level , and mRNA expression were correlated with better OS in all gastric patients, whereas , and mRNA expression were associated with poor OS. With regard to the clinicopathological features including Laurens classification, clinical stage, human epidermal growth factor receptor 2 (HER2) status, and different treatment strategy, we could illustrate significant role of individual mRNA expression in the prognosis of gastric cancer patients. Thus, our results indicated that AQP's protein and mRNA expression in gastric cancer patients provide effective role to predict prognosis and act as an essential agent to therapeutic strategy.

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References

Huang D, Feng X, Liu Y, Deng Y, Chen H, Chen D . AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer. Cell Death Dis. 2017; 8(6):e2894. PMC: 5520935. DOI: 10.1038/cddis.2017.282. View

Fischer H, Stenling R, Rubio C, Lindblom A . Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors. BMC Physiol. 2001; 1:1. PMC: 32180. DOI: 10.1186/1472-6793-1-1. View

Jian-Hui C, Er-Tao Z, Si-le C, Hui W, Kai-Ming W, Xin-Hua Z . CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection. Gastroenterol Res Pract. 2016; 2016:1013045. PMC: 4709647. DOI: 10.1155/2016/1013045. View

Zhu C, Chen Z, Jiang Z . Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines. Int J Mol Sci. 2016; 17(9). PMC: 5037679. DOI: 10.3390/ijms17091399. View

Magni F, Sarto C, Ticozzi D, Soldi M, Bosso N, Mocarelli P . Proteomic knowledge of human aquaporins. Proteomics. 2006; 6(20):5637-49. DOI: 10.1002/pmic.200600212. View

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T . Cancer statistics, 2008. CA Cancer J Clin. 2008; 58(2):71-96. DOI: 10.3322/CA.2007.0010. View

Leung J, Pang A, Yuen W, Kwong Y, Tse E . Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. Blood. 2006; 109(2):740-6. DOI: 10.1182/blood-2006-04-019588. View

Chen J, Wang T, Zhou Y, Gao F, Zhang Z, Xu H . Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer. J Exp Clin Cancer Res. 2014; 33:38. PMC: 4036310. DOI: 10.1186/1756-9966-33-38. View

Wang H, Liao X, Zhang J . Clinicopathological factors associated with HER2-positive gastric cancer: A meta-analysis. Medicine (Baltimore). 2017; 96(44):e8437. PMC: 5682803. DOI: 10.1097/MD.0000000000008437. View

10.

Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y . Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci. 2009; 59(2):113-22. PMC: 10717001. DOI: 10.1007/s12576-008-0017-3. View

11.

Kusayama M, Wada K, Nagata M, Ishimoto S, Takahashi H, Yoneda M . Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. Cancer Sci. 2011; 102(6):1128-36. DOI: 10.1111/j.1349-7006.2011.01927.x. View

12.

Asplund A, Edqvist P, Schwenk J, Ponten F . Antibodies for profiling the human proteome-The Human Protein Atlas as a resource for cancer research. Proteomics. 2012; 12(13):2067-77. DOI: 10.1002/pmic.201100504. View

13.

Tilghman S, Townley I, Zhong Q, Carriere P, Zou J, Llopis S . Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness. Mol Cell Proteomics. 2013; 12(9):2440-55. PMC: 3769322. DOI: 10.1074/mcp.M112.023861. View

14.

Beitz E, Liu K, Ikeda M, Guggino W, Agre P, Yasui M . Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells. Biol Cell. 2005; 98(2):101-9. DOI: 10.1042/BC20050025. View

15.

Laforenza U, Gastaldi G, Polimeni M, Tritto S, Tosco M, Ventura U . Aquaporin-6 is expressed along the rat gastrointestinal tract and upregulated by feeding in the small intestine. BMC Physiol. 2009; 9:18. PMC: 2765416. DOI: 10.1186/1472-6793-9-18. View

16.

Meza-Junco J, Sawyer M . Metastatic gastric cancer - focus on targeted therapies. Biologics. 2012; 6:137-46. PMC: 3395896. DOI: 10.2147/BTT.S23917. View

17.

Huang Y, Zhou X, Wang H, Xu H, Chen J, Lv N . Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumour Biol. 2013; 34(3):1743-51. DOI: 10.1007/s13277-013-0712-4. View

18.

Clapp C, Martinez de la Escalera G . Aquaporin-1: a novel promoter of tumor angiogenesis. Trends Endocrinol Metab. 2005; 17(1):1-2. DOI: 10.1016/j.tem.2005.11.009. View

19.

Hartgrink H, Jansen E, van Grieken N, van de Velde C . Gastric cancer. Lancet. 2009; 374(9688):477-90. PMC: 4613761. DOI: 10.1016/S0140-6736(09)60617-6. View

20.

Bhattacharjee H, Rosen B, Mukhopadhyay R . Aquaglyceroporins and metalloid transport: implications in human diseases. Handb Exp Pharmacol. 2008; (190):309-25. PMC: 2729095. DOI: 10.1007/978-3-540-79885-9_16. View