Autophagy As a Cytoprotective Mechanism in Esophageal Squamous Cell Carcinoma

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2018 Apr 21

PMID 29677645

Citations 14

Authors

Timothy M Hall

Marie-Pier Tetreault

Kathryn E Hamilton

Kelly A Whelan

Affiliations

Soon will be listed here.

Abstract

Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. Alterations in autophagy are associated with cancer pathogenesis, including ESCC; however, the functional role of autophagy in ESCC remains elusive. Here, we discuss the clinical relevance of autophagy effectors in ESCC and review current knowledge regarding the molecular mechanisms through which autophagy contributes to ESCC. We highlight the cytoprotective role of autophagy in ESCC and discuss autophagy inhibitors as novel experimental therapeutics to potentiate the effects of anti-cancer therapies and/or to overcome therapeutic resistance in ESCC.

Citing Articles

The Crosstalk Between Autophagy and MicroRNAs in Esophageal Carcinoma:.

Gorjizadeh N, Poudineh S, Barghgir B, Eghbali M, Sarlak A, Poudineh M Galen Med J. 2023; 12:e2903.

PMID: 37808004 PMC: 10556546. DOI: 10.31661/gmj.v12i.2903.

Long non-coding RNA LINC00707, a prognostic marker, regulates cell proliferation, apoptosis, and EMT in esophageal squamous cell carcinoma.

Gao N, Jiang G, Gao Z, Cui M, Li J, Liu H Am J Transl Res. 2023; 15(4):2426-2442.

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Spatial heterogeneity and Immune infiltration of cellular lysosomal pathways reveals a new blueprint for tumor heterogeneity in esophageal cancer.

Wei J, Wu X, Wang S, Liu S, Gao X Front Endocrinol (Lausanne). 2023; 14:1138457.

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PRR11 in Malignancies: Biological Activities and Targeted Therapies.

Han W, Chen L Biomolecules. 2022; 12(12).

PMID: 36551227 PMC: 9775115. DOI: 10.3390/biom12121800.

Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling.

Guo Z, Zhang Y Heliyon. 2022; 8(10):e11005.

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