Trans Dermal Estrogen (oestrogel) for Endometrial Preparation in Freeze Embryo Transfer Cycle: An RCT

Overview

Journal Int J Reprod Biomed

Specialty Reproductive Medicine

Date 2018 Apr 21

PMID 29675488

Citations 4

Authors

Ensieh Shahrokh Tehraninejad

Roya Kabodmehri

Batol Hosein Rashidi

Mina Jafarabadi

Fateme Keikha

Masomeh Masomi

Fedieh Hagholahi

Affiliations

Soon will be listed here.

Abstract

Background: Estrogen and progesterone are two crucial factors for endometrial preparation in frozen embryo transfer (FET) cycles. Studies assessing different forms of estradiol in FET have published already but literature lacks enough surveys on transdermal estrogen application in reproductive medicine.

Objective: To investigate the effects of trans dermal estrogen (Oestrogel) on pregnancy rates in patients that candidate for FET cycle.

Materials And Methods: In this randomized clinical trial, 100 women undergoing FET cycles referred to Imam Khomeeini Hospital were enrolled in two groups, randomly. Group I received 8 mg/day estradiol valerate (E2 tablet) orally and group II were treated with 6 mg/day transdermal oestrogel gel after suppression with gonadotropin releasing hormone agonist. In both groups medication were started in the first day of menstruation cycle and continued until endometrial thickness reached 8 mm. Pregnancy rates (chemical, clinical, and ongoing), abortion rate, live birth rate, and frequency of complications were compared between two groups.

Results: Chemical and clinical pregnancy rates were not significantly different between two groups (p=0.384). The abortion rate was significantly lower in group II than group I (p=0.035). Ongoing pregnancy and the live birth rates were significantly higher in group II (p=0.035). The rate of complication was not different in two groups.

Conclusion: Oestrogel seems to enhance ongoing pregnancy and live birth rates in comparison to estradiol valerate tablet.

Citing Articles

A randomized clinical trial of transdermal (gel) versus oral estrogen for endometrial preparation in frozen embryo transfer cycle.

Carvalho M, Lima S, Glina C, Tso L, Romano R, Glina S Rev Assoc Med Bras (1992). 2024; 70(5):e20231548.

PMID: 38775510 PMC: 11111116. DOI: 10.1590/1806-9282.20231548.

Effect of transdermal estrogen dose regimen for endometrial preparation of frozen-thawed embryo transfer on reproductive and obstetric outcomes.

Ogawa T, Kasai T, Ogi M, Fukushima J, Hirata S Reprod Med Biol. 2021; 20(2):208-214.

PMID: 33850454 PMC: 8022087. DOI: 10.1002/rmb2.12370.

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes.

Glujovsky D, Pesce R, Sueldo C, Quinteiro Retamar A, Hart R, Ciapponi A Cochrane Database Syst Rev. 2020; 10:CD006359.

PMID: 33112418 PMC: 8094620. DOI: 10.1002/14651858.CD006359.pub3.

Transdermal versus oral estrogen: clinical outcomes in patients undergoing frozen-thawed single blastocyst transfer cycles without GnRHa suppression, a prospective randomized clinical trial.

Kahraman S, Pirkevi Cetinkaya C, Sahin Y, Oner G J Assist Reprod Genet. 2018; 36(3):453-459.

PMID: 30519898 PMC: 6439127. DOI: 10.1007/s10815-018-1380-5.

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