Frizzled-related Proteins 4 (SFRP4) Rs1802073G Allele Predicts the Elevated Serum Lipid Levels During Acitretin Treatment in Psoriatic Patients from Hunan, China

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2018 Apr 19

PMID 29666772

Citations 5

Authors

Xingchen Zhou

Wu Zhu

Minxue Shen

Yijing He

Cong Peng

Yehong Kuang

Juan Su

Shuang Zhao

Xiang Chen

Wangqing Chen

Affiliations

Soon will be listed here.

Abstract

Background: Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin.

Methods: In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients' demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment.

Results: A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs -1.47 ± 37.79, = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs -1.29 ± 17.07, = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL.

Conclusions: Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

Citing Articles

17 variants interaction of Wnt/β-catenin pathway associated with development of osteonecrosis of femoral head in Chinese Han population.

Shi C, Li X, Sun Y, Du Z, Zhang G, Che Z Sci Rep. 2024; 14(1):7301.

PMID: 38538713 PMC: 10973331. DOI: 10.1038/s41598-024-57929-8.

Federated Machine Learning for Skin Lesion Diagnosis: An Asynchronous and Weighted Approach.

Mateen Yaqoob M, Alsulami M, Amir Khan M, Alsadie D, Jilani Saudagar A, Alkhathami M Diagnostics (Basel). 2023; 13(11).

PMID: 37296816 PMC: 10252842. DOI: 10.3390/diagnostics13111964.

Pharmaco-Omics in Psoriasis: Paving the Way towards Personalized Medicine.

Antonatos C, Asmenoudi P, Panoutsopoulou M, Vasilopoulos Y Int J Mol Sci. 2023; 24(8).

PMID: 37108251 PMC: 10139144. DOI: 10.3390/ijms24087090.

Towards Personalized Medicine in Psoriasis: Current Progress.

Camela E, Potestio L, Ruggiero A, Ocampo-Garza S, Fabbrocini G, Megna M Psoriasis (Auckl). 2022; 12:231-250.

PMID: 36071793 PMC: 9444142. DOI: 10.2147/PTT.S328460.

Polymorphisms of SLCO1B1 rs4149056 and SLC22A1 rs2282143 are associated with responsiveness to acitretin in psoriasis patients.

Chen W, Zhang X, Zhang W, Peng C, Zhu W, Chen X Sci Rep. 2018; 8(1):13182.

PMID: 30181619 PMC: 6123456. DOI: 10.1038/s41598-018-31352-2.

References

Orfanos C, Zouboulis C, Geilen C . Current use and future potential role of retinoids in dermatology. Drugs. 1997; 53(3):358-88. DOI: 10.2165/00003495-199753030-00003. View

Grayson M . Psoriasis. Nature. 2012; 492(7429):S49. DOI: 10.1038/492S49a. View

Mi K, Johnson G . Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway. J Cell Biochem. 2005; 95(2):328-38. DOI: 10.1002/jcb.20400. View

Carmon K, Loose D . Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Mol Cancer Res. 2008; 6(6):1017-28. DOI: 10.1158/1541-7786.MCR-08-0039. View

Nozaki Y, Kumagai K, Miyata N, Niwa M . Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats. Acta Orthop. 2012; 83(1):87-92. PMC: 3278663. DOI: 10.3109/17453674.2011.641103. View

Wu L, Li F, Sun L, Li D, Su J, Kuang Y . A miRNA-492 binding-site polymorphism in BSG (basigin) confers risk to psoriasis in central south Chinese population. Hum Genet. 2011; 130(6):749-57. DOI: 10.1007/s00439-011-1026-5. View

Campalani E, Allen M, Fairhurst D, Young H, Mendonca C, Burden A . Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Br J Dermatol. 2006; 154(2):345-52. DOI: 10.1111/j.1365-2133.2005.06950.x. View

Dogra S, Yadav S . Acitretin in psoriasis: an evolving scenario. Int J Dermatol. 2014; 53(5):525-38. DOI: 10.1111/ijd.12365. View

Bowcock A . The genetics of psoriasis and autoimmunity. Annu Rev Genomics Hum Genet. 2005; 6:93-122. DOI: 10.1146/annurev.genom.6.080604.162324. View

10.

Nemati H, Houshang N, Khodarahmi R, Reza K, Sadeghi M, Masoud S . Antioxidant status in patients with psoriasis. Cell Biochem Funct. 2014; 32(3):268-273. DOI: 10.1002/cbf.3011. View

11.

Tomaszewski M, Charchar F, Barnes T, Gawron-Kiszka M, Sedkowska A, Podolecka E . A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol. 2009; 29(9):1316-21. PMC: 2814817. DOI: 10.1161/ATVBAHA.109.185355. View

12.

Go G, Mani A . Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis. Yale J Biol Med. 2012; 85(1):19-28. PMC: 3313535. View

13.

Hirata H, Hinoda Y, Nakajima K, Kikuno N, Yamamura S, Kawakami K . Wnt antagonist gene polymorphisms and renal cancer. Cancer. 2009; 115(19):4488-503. PMC: 3940366. DOI: 10.1002/cncr.24491. View

14.

Lee D, Kim H, Ku S, Kim S, Choi Y, Kim J . Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. Menopause. 2010; 17(5):1064-70. DOI: 10.1097/gme.0b013e3181da4da3. View

15.

Walsh J, Andrews P . Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell. APMIS. 2003; 111(1):197-210; discussion 210-1. DOI: 10.1034/j.1600-0463.2003.1110124.x. View

16.

Ormerod A, Campalani E, Goodfield M . British Association of Dermatologists guidelines on the efficacy and use of acitretin in dermatology. Br J Dermatol. 2010; 162(5):952-63. DOI: 10.1111/j.1365-2133.2010.09755.x. View

17.

Borrell-Pages M, Romero J, Badimon L . LRP5 and plasma cholesterol levels modulate the canonical Wnt pathway in peripheral blood leukocytes. Immunol Cell Biol. 2015; 93(7):653-61. DOI: 10.1038/icb.2015.41. View

18.

Balta I, Balta S, Cakar M, Demirkol S, Celik T . Psoriasis treatment should be stratified in order to better assess the cardiovascular event rates. J Intern Med. 2013; 274(3):288-9. DOI: 10.1111/joim.12079. View

19.

Foer D, Zhu M, Cardone R, Simpson C, Sullivan R, Nemiroff S . Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis. Osteoporos Int. 2017; 28(6):2011-2017. PMC: 6693506. DOI: 10.1007/s00198-017-3977-4. View

20.

Liu P, He Y, Wang H, Kuang Y, Chen W, Li J . The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis. J Dermatol Sci. 2018; 89(3):233-240. DOI: 10.1016/j.jdermsci.2017.11.007. View