Kisspeptin and Cancer: Molecular Interaction, Biological Functions, and Future Perspectives

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2018 Apr 18

PMID 29662466

Citations 14

Authors

Vincenza Ciaramella

Carminia Maria Della Corte

Fortunato Ciardiello

Floriana Morgillo

Affiliations

Soon will be listed here.

Abstract

Cancer disease is the second leading cause of death in the world and one of the main fields of medical research. Although there is now a greater understanding of biological mechanisms of uncontrolled cell growth, invasiveness and metastasization, the multi-step process of cancer development and evolution is still incompletely understood. The inhibition of molecules activated in cancer metastasization is an hot topic in cancer research. Among the known antimetastatic genes, KiSS-1 is involved in the metastatic cascade by preventing growth of metastasis. Moreover, loss of KiSS-1 protein expression by tumor cells has been associated with a more aggressive phenotype. gene encodes a 145-amino acid protein, which following proteolytic cleavage, generates a family of kisspeptins (Kp-10, -13, and -14), that are endogenous agonists for the G-protein-coupled receptor (GPR54). The antitumor effect of KiSS-1 was primarily associated with the inhibition of proliferation, migration and cell invasion and, consequently, the reduced formation of metastasis and intratumoral microvessels. In this review, we highlight the latest data on the role of kisspeptin signaling in the suppression of metastasis in various cancer types and the use modulators of KiSS/GPR54 signaling as potential novel therapeutic agents for the treatment of cancer.

Citing Articles

KiSS-1 Modulation by Epigenetic Agents Improves the Cisplatin Sensitivity of Lung Cancer Cells.

Beretta G, Alampi D, Corno C, Carenini N, Corna E, Perego P Int J Mol Sci. 2024; 25(9).

PMID: 38732265 PMC: 11084743. DOI: 10.3390/ijms25095048.

Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy.

Dinh H, Kovacs Z, Kis M, Kupecz K, Sejben A, Szucs G Geroscience. 2023; 46(2):2463-2488.

PMID: 37987885 PMC: 10828495. DOI: 10.1007/s11357-023-01017-8.

Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue.

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YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations.

Cunningham R, Jia S, Purohit K, Salem O, Hui N, Lin Y Clin Transl Med. 2023; 13(2):e1190.

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Inverse Correlation of KISS1 and KISS1R Expression in Triple-negative Breast Carcinomas from African American Women.

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PMID: 36316037 PMC: 9620443. DOI: 10.21873/cgp.20350.

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