Body Mass Index, Sitting Time, and Risk of Parkinson Disease

Overview

Journal Neurology

Specialty Neurology

Date 2018 Apr 18

PMID 29661903

Citations 16

Authors

Elin Roos

Alessandra Grotta

Fei Yang

Rino Bellocco

Weimin Ye

Hans-Olov Adami

Karin Wirdefeldt

Ylva Trolle Lagerros

Affiliations

Soon will be listed here.

Abstract

Objective: Causes of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures.

Methods: We prospectively analyzed a cohort of 41,638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs).

Results: We identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76-1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60-2.12) for body mass index ≥30 vs <25 kg/m. Results did not differ by sex.

Conclusions: No association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.

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