Hemophagocytic Lymphohistiocytosis (HLH) Secondary to Disseminated Histoplasmosis in the Setting of Acquired Immunodeficiency Syndrome (AIDS)

Overview

Journal Med Mycol Case Rep

Publisher Elsevier

Date 2018 Apr 17

PMID 29657917

Citations 11

Authors

Samuel Asanad

Brendan Cerk

Veronica Ramirez

Affiliations

Soon will be listed here.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease involving immune system over-activation leading to hemophagocytosis. HLH requires early diagnosis and prompt treatment initiation, especially in patients with Acquired Immunodeficiency Syndrome (AIDS). We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on anti-fungal therapy. Anti-retroviral therapy followed thereafter.

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