Low Serum Levels of Vitamin D Are Associated with Anxiety in Children and Adolescents with Dialysis

Overview

Journal Sci Rep

Specialty Science

Date 2018 Apr 15

PMID 29654252

Citations 10

Authors

Bin Han

Fu-Xiang Zhu

Hai-Feng Yu

Si Liu

Jun-Liang Zhou

Affiliations

Soon will be listed here.

Abstract

Anxiety is a frequent and serious complication of children and adolescents receiving dialysis. Low serum vitamin D levels have been associated with anxiety in non-pediatric patients. This study sought to examine the possible association between serum vitamin D levels and the presence of anxiety in children and adolescents with dialysis in China. A total of 156 pediatric patients who were on hemodialysis or peritoneal dialysis and 100 healthy controls were included in the current study. Serum 25-hydroxyvitamin D [25(OH)D] levels were measured by using a competitive protein-binding assay. Anxiety was assessed by using the Chinese version of the Screen for Child Anxiety Related Emotional Disorders (SCARED, = 25 as cutoff). Among 156 patients, 110 had a current anxiety (70.5%) and 46 did not (29.5%). Serum levels of 25(OH)D were significantly lower in patients with anxiety than in normal controls (19.4 ± 10.3 vs. 38.6 ± 15.5 ng/ml, P < 0.001). Serum 25(OH)D levels (≤15.0 ng/ml) were independently associated with the existent of anxiety in children and adolescents receiving dialysis (OR 4.650, 95% CI 1.663-13.001, P = 0.003). Our research demonstrates that low serum levels of vitamin D are independently associated with anxiety among children and adolescents on dialysis, which needs to be confirmed in future experimental and clinical studies.

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References

Eyles D, Burne T, McGrath J . Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 2012; 34(1):47-64. DOI: 10.1016/j.yfrne.2012.07.001. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Cetin N, Sav N, Karabel D, Yildirim A, Yildiz B . Serum albumin and von Willebrand factor: possible markers for early detection of vascular damage in children undergoing peritoneal dialysis. Clin Invest Med. 2016; 39(4):E111-9. DOI: 10.25011/cim.v39i4.27090. View

Stewart A, Wong K, Cachat J, Elegante M, Gilder T, Mohnot S . Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology. Behav Pharmacol. 2010; 21(5-6):420-6. DOI: 10.1097/FBP.0b013e32833c850f. View

Birmaher B, Brent D, Chiappetta L, Bridge J, Monga S, Baugher M . Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry. 1999; 38(10):1230-6. DOI: 10.1097/00004583-199910000-00011. View

Fedotova J, Pivina S, Sushko A . Effects of Chronic Vitamin D₃ Hormone Administration on Anxiety-Like Behavior in Adult Female Rats after Long-Term Ovariectomy. Nutrients. 2017; 9(1). PMC: 5295072. DOI: 10.3390/nu9010028. View

Kilis-Pstrusinska K, Medynska A, Adamczak P, Balasz-Chmielewska I, Grenda R, Kluska-Jozwiak A . Anxiety in children and adolescents with chronic kidney disease--multicenter national study results. Kidney Blood Press Res. 2013; 37(6):579-87. DOI: 10.1159/000355738. View

Bellia A, Garcovich C, DAdamo M, Lombardo M, Tesauro M, Donadel G . Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects. Intern Emerg Med. 2011; 8(1):33-40. DOI: 10.1007/s11739-011-0559-x. View

Kelley L, Sanders A, Beaton E . Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome. J Dev Orig Health Dis. 2016; 7(6):616-625. PMC: 5922262. DOI: 10.1017/S2040174416000428. View

10.

Tartagni M, Cicinelli M, Tartagni M, Alrasheed H, Matteo M, Baldini D . Vitamin D Supplementation for Premenstrual Syndrome-Related Mood Disorders in Adolescents with Severe Hypovitaminosis D. J Pediatr Adolesc Gynecol. 2016; 29(4):357-61. DOI: 10.1016/j.jpag.2015.12.006. View

11.

Cai W, Khaoustov V, Xie Q, Pan T, Le W, Yoffe B . Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. J Hepatol. 2005; 42(6):880-7. DOI: 10.1016/j.jhep.2005.01.024. View

12.

Armstrong D, Meenagh G, Bickle I, Lee A, Curran E, Finch M . Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2006; 26(4):551-4. DOI: 10.1007/s10067-006-0348-5. View

13.

Moron J, Zakharova I, Ferrer J, Merrill G, Hope B, Lafer E . Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. J Neurosci. 2003; 23(24):8480-8. PMC: 6740378. View

14.

Dibas B, Warady B . Vitamin D status of children receiving chronic dialysis. Pediatr Nephrol. 2012; 27(10):1967-73. DOI: 10.1007/s00467-012-2203-z. View

15.

Eyles D, Smith S, Kinobe R, Hewison M, McGrath J . Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2004; 29(1):21-30. DOI: 10.1016/j.jchemneu.2004.08.006. View

16.

Bakr A, Amr M, Sarhan A, Hammad A, Ragab M, El-Refaey A . Psychiatric disorders in children with chronic renal failure. Pediatr Nephrol. 2006; 22(1):128-31. DOI: 10.1007/s00467-006-0298-9. View

17.

Polanska B, Augustyniak D, Makulska I, Niemczuk M, Jankowski A, Zwolinska D . Elastase, α1-proteinase inhibitor, and interleukin-8 in children and young adults with end-stage kidney disease undergoing continuous ambulatory peritoneal dialysis. Arch Immunol Ther Exp (Warsz). 2013; 62(3):239-45. PMC: 4024125. DOI: 10.1007/s00005-013-0265-7. View

18.

Bicikova M, Duskova M, Vitku J, Kalvachova B, ripova D, Mohr P . Vitamin D in anxiety and affective disorders. Physiol Res. 2015; 64(Suppl 2):S101-3. DOI: 10.33549/physiolres.933082. View

19.

Fukunishi I, Honda M, Kamiyama Y, Ito H . Anxiety disorders and pediatric continuous ambulatory peritoneal dialysis. Child Psychiatry Hum Dev. 1993; 24(1):59-64. DOI: 10.1007/BF02353719. View

20.

Wrzosek M, Lukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piatkiewicz P . Vitamin D and the central nervous system. Pharmacol Rep. 2013; 65(2):271-8. DOI: 10.1016/s1734-1140(13)71003-x. View