Polymeric Micelles: Theranostic Co-delivery System for Poorly Water-soluble Drugs and Contrast Agents

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2018 Apr 13

PMID 29649747

Citations 19

Authors

Jaydev R Upponi

Kaushal Jerajani

Dattatri K Nagesha

Praveen Kulkarni

Srinivas Sridhar

Craig Ferris

Vladimir P Torchilin

Affiliations

Soon will be listed here.

Abstract

Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.

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