Brazilian Medicinal Plants with Corroborated Anti-inflammatory Activities: a Review

Overview

Journal Pharm Biol

Specialties Pharmacology
Pharmacy

Date 2018 Apr 13

PMID 29648503

Citations 25

Authors

Victor Pena Ribeiro

Caroline Arruda

Mohamed Abd El-Salam

Jairo Kenupp Bastos

Affiliations

Soon will be listed here.

Abstract

Context: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity.

Objectives: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds.

Methods: A search in the literature was undertaken by using the following Web tools: Web of Science, SciFinder, Pub-Med and Science Direct. The terms 'anti-inflammatory' and 'Brazilian medicinal plants' were used as keywords in search engine. Tropicos and Reflora websites were used to verify the origin of the plants, and only the native plants of Brazil were included in this review. The publications reporting the use of well-accepted scientific protocols to corroborate the anti-inflammatory activities of Brazilian medicinal plants with anti-inflammatory potential were considered.

Results: We selected 70 Brazilian medicinal plants with anti-inflammatory activity. The plants were grouped according to their anti-inflammatory mechanisms of action. The main mechanisms involved inflammatory mediators, such as interleukins (ILs), nuclear factor kappa B (NF-κB), prostaglandin E2 (PGE2), cyclooxygenase (COX) and reactive oxygen species (ROS).

Conclusions: The collected data on Brazilian medicinal plants, in the form of crude extract and/or isolated compounds, showed significant anti-inflammatory activities involving different mechanisms of action, indicating Brazilian plants as an important source of anti-inflammatory compounds.

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References

dos Santos D, Fukui M, Nanayakkara N, Khan S, Sousa J, Bastos J . Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models. J Ethnopharmacol. 2009; 127(2):543-50. DOI: 10.1016/j.jep.2009.09.061. View

Ahn E, Jeon H, Lim E, Jung H, Park E . Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol. 2006; 110(3):476-82. DOI: 10.1016/j.jep.2006.10.006. View

Salvemini D, DOYLE T, Cuzzocrea S . Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. Biochem Soc Trans. 2006; 34(Pt 5):965-70. DOI: 10.1042/BST0340965. View

Recio M, Prieto M, Bonucelli M, Orsi C, Manez S, Giner R . Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. Planta Med. 2004; 70(5):414-20. DOI: 10.1055/s-2004-818968. View

Kupeli E, Kosar M, Yesilada E, Husnu K, Baser C . A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. Life Sci. 2002; 72(6):645-57. DOI: 10.1016/s0024-3205(02)02200-2. View

da Silva Filho A, Andrade E Silva M, Carvalho J, Bastos J . Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats. J Pharm Pharmacol. 2004; 56(9):1179-84. DOI: 10.1211/0022357044058. View

Pimentel S, Barrella G, Casarin R, Cirano F, Casati M, Foglio M . Protective effect of topical Cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays. BMC Complement Altern Med. 2012; 12:224. PMC: 3522563. DOI: 10.1186/1472-6882-12-224. View

Ghasemian M, Owlia S, Owlia M . Review of Anti-Inflammatory Herbal Medicines. Adv Pharmacol Sci. 2016; 2016:9130979. PMC: 4877453. DOI: 10.1155/2016/9130979. View

Chan C, Tan L, Andy S, Kamarudin M, Goh B, Kadir H . Anti-neuroinflammatory Activity of L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells. Front Pharmacol. 2017; 8:397. PMC: 5478732. DOI: 10.3389/fphar.2017.00397. View

10.

Fierro I, Da Silva A, Lopes C, DE MOURA R, Barja-Fidalgo C . Studies on the anti-allergic activity of Mikania glomerata. J Ethnopharmacol. 1999; 66(1):19-24. DOI: 10.1016/s0378-8741(98)00151-2. View

11.

Kundu J, Surh Y . Emerging avenues linking inflammation and cancer. Free Radic Biol Med. 2012; 52(9):2013-37. DOI: 10.1016/j.freeradbiomed.2012.02.035. View

12.

da Silva L, Farias J, Boeing T, Somensi L, Beber A, Cury B . Hydroalcoholic Extract from Inflorescences of (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators. Evid Based Complement Alternat Med. 2016; 2016:3475356. PMC: 5099481. DOI: 10.1155/2016/3475356. View

13.

Aherne S, OBrien N . Dietary flavonols: chemistry, food content, and metabolism. Nutrition. 2002; 18(1):75-81. DOI: 10.1016/s0899-9007(01)00695-5. View

14.

Kassuya C, Cremoneze A, Barros L, Simas A, da Rocha Lapa F, Mello-Silva R . Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). J Ethnopharmacol. 2009; 124(3):369-76. DOI: 10.1016/j.jep.2009.06.003. View

15.

Guenka L, Gomes R, Melo V, Kitanishi C, Pereira P, Franca S . Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract. Mem Inst Oswaldo Cruz. 2009; 103(8):768-72. DOI: 10.1590/s0074-02762008000800004. View

16.

Andrade S, Cardoso L, Carvalho J, Bastos J . Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. J Ethnopharmacol. 2006; 109(3):464-71. DOI: 10.1016/j.jep.2006.08.023. View

17.

Allen-Hall L, Cano P, Arnason J, Rojas R, Lock O, Lafrenie R . Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha. J Ethnopharmacol. 2006; 109(2):312-7. DOI: 10.1016/j.jep.2006.07.039. View

18.

Nardi G, Felippi R, DALBO S, Siqueira-Junior J, Arruda D, Delle Monache F . Anti-inflammatory and antioxidant effects of Croton celtidifolius bark. Phytomedicine. 2003; 10(2-3):176-84. DOI: 10.1078/094471103321659906. View

19.

Viegas Jr C, Alexandre-Moreira M, Fraga C, Barreiro E, da Silva Bolzani V, Palhares de Miranda A . Antinociceptive profile of 2,3,6-trisubstituted piperidine alkaloids: 3-O-acetyl-spectaline and semi-synthetic derivatives of (-)-spectaline. Chem Pharm Bull (Tokyo). 2008; 56(4):407-12. DOI: 10.1248/cpb.56.407. View

20.

Pereira L, da Silva R, de Souza Ferreira Bringel P, da Silva K, Assreuy A, Pereira M . Polysaccharide fractions of Caesalpinia ferrea pods: potential anti-inflammatory usage. J Ethnopharmacol. 2011; 139(2):642-8. DOI: 10.1016/j.jep.2011.12.012. View