SIRT3: A New Regulator of Cardiovascular Diseases

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2018 Apr 13

PMID 29643974

Citations 76

Authors

Wei Sun

Caixia Liu

Qiuhui Chen

Ning Liu

Youyou Yan

Bin Liu

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD-dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle, oxidative stress, and apoptosis by reversible protein lysine deacetylation. SIRT3 regulates glucose and lipid metabolism and maintains myocardial ATP levels, which protects the heart from metabolic disturbances. SIRT3 can also protect cardiomyocytes from oxidative stress-mediated cell damage and block the development of cardiac hypertrophy. Recent reports show that SIRT3 is involved in the protection of several heart diseases. This review discusses the progress in SIRT3-related research and the role of SIRT3 in the prevention and treatment of CVDs.

Citing Articles

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The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart.

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THRA1/PGC-1α/SIRT3 pathway regulates oxidative stress and is implicated in hypertension of maternal hypothyroid rat offspring.

Guo J, Shi Y, Yu X, Zhao Y, Wei B, Huo M Hypertens Res. 2024; 48(3):1080-1098.

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SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells.

Peng P, Lu Y, Ren X, Yan C, Guo X, Liu R iScience. 2024; 27(11):111176.

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Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis.

Zou H, Zhang M, Yang X, Shou H, Chen Z, Zhu Q J Zhejiang Univ Sci B. 2024; 25(9):756-772.

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