Heart Regeneration in Adult Mammals After Myocardial Damage

Overview

Journal Acta Cardiol Sin

Date 2018 Apr 13

PMID 29643696

Citations 11

Authors

Baiping Cui

Yufan Zheng

Lihua Sun

Ting Shi

Ziyu Shi

Lijue Wang

Guoying Huang

Ning Sun

Affiliations

Soon will be listed here.

Abstract

Heart regeneration remains a critical question in current basic research and clinical practice. The adult mammalian heart exhibits a very limited regeneration capacity. In contrast, adult zebrafish and neonatal mice retain a remarkable ability of heart regeneration after damage. Understanding the mechanisms of heart regeneration would be very valuable to help design efficient treatment strategies against myocardial damage and heart failure. While inherent regeneration of the heart occurs after damage with varying efficiency among species, regeneration may also be induced exogenously. In this study, we briefly review the different approaches and current progress in improving heart regeneration.

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