Orofacial Granulomatosis and Diet Therapy: a Review of the Literature and Two Clinical Cases

Overview

Journal An Bras Dermatol

Specialty Dermatology

Date 2018 Apr 12

PMID 29641703

Citations 7

Authors

Iris Espinoza

Jorge Navarrete

Juana Benedetto

Arturo Borzutzky

Patricia Roessler

Ana Ortega-Pinto

Affiliations

Soon will be listed here.

Abstract

Orofacial granulomatosis is a nonspecific term that contains a wide variety of granulomatous entities, which share a clinical and histopathological presentation. It manifests as persistent or recurrent orofacial swelling, amongst other findings. Idiopathic orofacial granulomatosis, characterized by an absence of systemic granulomatous disease, is a diagnosis of exclusion. The main differential diagnosis is Crohn's disease. Its pathogenesis is unknown, however, it seems to be immune-mediated. Patch-test sensitivity to multiple allergens is well documented. Currently, therapeutic options consider restrictive diets, topical, intralesional, and systemic agents. First-line therapy is currently a matter of debate. We present a review of the value of diet therapy in this syndrome, along with two illustrative cases.

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