Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study

Overview

Journal J Am Geriatr Soc

Specialty Geriatrics

Date 2018 Apr 12

PMID 29637543

Citations 11

Authors

Andrea L Rosso

Andrea L Metti

Nancy W Glynn

Robert M Boudreau

W Jack Rejeski

Nicolaas Bohnen

Haiying Chen

Neil M Johannsen

Abby C King

Todd M Manini

Marco Pahor

Stephanie A Studenski

Carlos A Vaz Fragoso

Caterina Rosano

Affiliations

Soon will be listed here.

Abstract

Objectives: To determine whether intervention-induced physical activity (PA) changes in sedentary older adults differed according to dopamine-related genotype.

Design: Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial (2010-13)).

Setting: Multicenter study, 8 U.S.

Locations:

Participants: Volunteer sample of sedentary adults aged 70 to 89 at risk of disability (N=1635).

Interventions: Structured PA versus health education (HE) for an average of 2.6 years.

Measurements: Single-nucleotide polymorphisms of dopamine-related genes (dopamine receptor (DR) D1, DRD2, DRD3, and catechol-O-methyltransferase (COMT)) were assessed. Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min/d) at baseline and 6, 12, and 24 months. Between-arm MVPA differences according to genotype and genotype with square root-transformed MVPA separately according to arm were tested, stratified according to race, and adjusted for multiple comparisons.

Results: White participants in the PA arm (n=513) had higher average square root transformed MVPA (4.91±1.91)than those in the HE arm (n=538) (4.51±1.82) (p=.001). Between-arm differences were greater for DRD2 Met/Met (high dopamine; HE: 4.76±1.80, PA: 5.53±1.60, p=.03) than Val/Val (low dopamine; HE: 4.58±1.92, PA: 4.81±1.83, p=.16); results were similar for COMT. In the PA arm, DRD2 Met/Met was associated with higher average MVPA (5.39±2.00) than Met/Val (4.46±2.51) (p=.01) and Val/Val (4.65±2.71) (p=.01). There were no associations for other genes. Associations were not significant in blacks but followed similar trends.

Conclusion: Higher dopamine signaling may support changes in PA during an intervention. The role of dopamine-related pathways in promoting PA participation and enhancing response to interventions in sedentary older adults should be studied.

Trial Registration: clinicaltrials.gov Identifier: NCT01072500.

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