Rett Syndrome from Bench to Bedside: Recent Advances

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2018 Apr 12

PMID 29636907

Citations 8

Authors

Yann Ehinger

Valerie Matagne

Laurent Villard

Jean-Christophe Roux

Affiliations

Soon will be listed here.

Abstract

Rett Syndrome is a severe neurological disorder mainly due to mutations in the methyl-CpG-binding protein 2 gene ( ). Mecp2 is known to play a role in chromatin organization and transcriptional regulation. In this review, we report the latest advances on the molecular function of Mecp2 and the new animal and cellular models developed to better study Rett syndrome. Finally, we present the latest innovative therapeutic approaches, ranging from classical pharmacology to correct symptoms to more innovative approaches intended to cure the pathology.

Citing Articles

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Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders.

Malar D, Thitilertdecha P, Ruckvongacheep K, Brimson S, Tencomnao T, Brimson J CNS Drugs. 2023; 37(5):399-440.

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A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency.

Li H, Hu M, Huang Z, Wang Y, Xu Y, Deng J Front Immunol. 2023; 13:1056447.

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Modeling Neurodevelopmental and Neuropsychiatric Diseases with Astrocytes Derived from Human-Induced Pluripotent Stem Cells.

Ren B, Dunaevsky A Int J Mol Sci. 2021; 22(4).

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Multisite Study of Evoked Potentials in Rett Syndrome.

Saby J, Benke T, Peters S, Standridge S, Matsuzaki J, Cutri-French C Ann Neurol. 2021; 89(4):790-802.

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