Sleep Disordered Breathing Controlled by CPAP and SFlt-1 in a Pregnant Patient with Chronic Hypertension: Case Report and Literature Review

Overview

Journal Obstet Med

Specialty Gynecology & Obstetrics

Date 2018 Apr 12

PMID 29636812

Citations 3

Authors

Amy Daly

Annette Robertson

Gabriele Bobek

Sally Middleton

Colin Sullivan

Annemarie Hennessy

Affiliations

Soon will be listed here.

Abstract

Background: There is recent interest exploring the possible impact of sleep disordered breathing on the mechanisms of preeclampsia. A biomarker of preeclampsia, soluble fms-like tyrosine kinase-1, has come to prominence in recent years. The aim of this study was to investigate the relationship between continuous positive airway pressure treatment, sleep disordered breathing and soluble fms-like tyrosine kinase-1 concentrations during pregnancy.

Methods: A 38-year-old G1P0 presented at 20 + 5 weeks. She had a history of chronic hypertension. Sleep studies revealed she had sleep disordered breathing with an AHI of 7.3/h. She was commenced on continuous positive airway pressure. Soluble fms-like tyrosine kinase-1 concentrations and blood pressure recordings were taken at various points during her pregnancy.

Results: She did not develop preeclampsia or require an escalation in her antihypertensives. Soluble fms-like tyrosine kinase-1 concentrations rose 16% from a low baseline. She remained compliant with her continuous positive airway pressure. She progressed to birth a well, live, term baby.

Conclusion: Continuous positive airway pressure treatment controlled sleep disordered breathing in a high risk pregnant woman with chronic hypertension with no increase in soluble fms-like tyrosine kinase-1 concentrations.

Citing Articles

Continuous Positive Airway Pressure Treatment and Hypertensive Adverse Outcomes in Pregnancy: A Systematic Review and Meta-Analysis.

Lee Y, Chang Y, Tseng L, Lin W, Lu C, Lee L JAMA Netw Open. 2024; 7(8):e2427557.

PMID: 39136943 PMC: 11322849. DOI: 10.1001/jamanetworkopen.2024.27557.

Treatment of obstructive sleep apnea in high risk pregnancy: a multicenter randomized controlled trial.

Tantrakul V, Ingsathit A, Liamsombut S, Rattanasiri S, Kittivoravitkul P, Imsom-Somboon N Respir Res. 2023; 24(1):171.

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The etiology of preeclampsia.

Jung E, Romero R, Yeo L, Gomez-Lopez N, Chaemsaithong P, Jaovisidha A Am J Obstet Gynecol. 2022; 226(2S):S844-S866.

PMID: 35177222 PMC: 8988238. DOI: 10.1016/j.ajog.2021.11.1356.

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