Perinatal Management of Hepatitis B Virus: Clinical Implementation of Updated Australasian Management Guidelines

Overview

Journal Obstet Med

Specialty Gynecology & Obstetrics

Date 2018 Apr 12

PMID 29636810

Citations 1

Authors

Hannah Bergin

Gillian Wood

Susan P Walker

Lisa Hui

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the implementation of the 2013 Royal Australian and New Zealand College of Obstetricians and Gynaecologists guideline.

Methods: Retrospective cohort study of the clinical management and obstetric outcomes among hepatitis B virus-positive women in a single tertiary maternity hospital. Women with viral load >200,000 IU/ml were referred to a specialised clinic for consideration of tenofovir disoproxil fumarate therapy to reduce mother to child transmission.

Results: A total of 11,496 women gave birth during the study period, of which 101 (0.9%) women were hepatitis B virus positive. Viral load was measured in 99 (98%) of 101 hepatitis B virus-positive women; 30 (30%) had a viral load >200,000 IU/ml. Twenty-six women accepted tenofovir disoproxil fumarate; of these, 23 had a successful virological response (viral load <200,000 IU/ml before delivery).

Conclusions: Adherence to updated management guidelines and patient acceptance of tenofovir disoproxil fumarate in our Australian population were high when provided in the context of a dedicated perinatal service.

Citing Articles

Hepatitis B clinical care provision in pregnancy: A whole-of-population linkage study in Victoria, Australia.

MacLachlan J, Romero N, Allard N, Rowe S, Cowie B J Gastroenterol Hepatol. 2024; 39(11):2377-2385.

PMID: 39104039 PMC: 11618317. DOI: 10.1111/jgh.16711.

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