Immunization of Domestic Ducks with Live Nonpathogenic H5N3 Influenza Virus Prevents Shedding and Transmission of Highly Pathogenic H5N1 Virus to Chickens

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2018 Apr 5

PMID 29614716

Citations 1

Authors

Alexandra Gambaryan

Ilya Gordeychuk

Elizaveta Boravleva

Natalia Lomakina

Ekaterina Kropotkina

Andrey Lunitsin

Hans-Dieter Klenk

Mikhail Matrosovich

Affiliations

Soon will be listed here.

Abstract

Wild ducks are known to be able to carry avian influenza viruses over long distances and infect domestic ducks, which in their turn infect domestic chickens. Therefore, prevention of virus transmission between ducks and chickens is important to control the spread of avian influenza. Here we used a low pathogenic wild aquatic bird virus A/duck/Moscow/4182/2010 (H5N3) for prevention of highly pathogenic avian influenza virus (HPAIV) transmission between ducks and chickens. We first confirmed that the ducks orally infected with H5N1 HPAIV A/chicken/Kurgan/3/2005 excreted the virus in feces. All chickens that were in contact with the infected ducks became sick, excreted the virus, and died. However, the ducks orally inoculated with 10⁴ 50% tissue culture infective doses of A/duck/Moscow/4182/2010 and challenged 14 to 90 days later with H5N1 HPAIV did not excrete the challenge virus. All contact chickens survived and did not excrete the virus. Our results suggest that low pathogenic virus of wild aquatic birds can be used for prevention of transmission of H5N1 viruses between ducks and chickens.

Citing Articles

Avian influenza overview February - May 2018.

Adlhoch C, Brouwer A, Kuiken T, Mulatti P, Smietanka K, Staubach C EFSA J. 2020; 16(6):e05358.

PMID: 32625951 PMC: 7009712. DOI: 10.2903/j.efsa.2018.5358.

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