Analgesic Effect of S (+)-flurbiprofen Plaster in a Rat Model of Knee Arthritis: Analysis of Gait and Synovial Fluid Prostaglandin E Levels

Overview

Journal J Pharm Pharmacol

Publisher Oxford University Press

Specialties Pharmacology
Pharmacy

Date 2018 Apr 3

PMID 29607510

Citations 5

Authors

Ayaka Fukumoto

Kyoko Tajima

Miyuki Hori

Yoshihisa Toda

Shinsuke Kaku

Hideo Matsumoto

Affiliations

Soon will be listed here.

Abstract

Objectives: We developed S (+)-flurbiprofen plaster (SFPP), a novel NSAID patch containing S (+)-flurbiprofen (SFP), a potent cyclooxygenase (COX) inhibitor. The purpose of this study was to assess efficacy of SFPP by analysing its effect on the gait disturbance and measuring the prostaglandin E (PGE ) production in synovial fluid in a rat model of knee arthritis.

Methods: Knee inflammation was induced in rats by intra-articular injection of a yeast suspension. Subsequently, an NSAID patch containing SFP, ketoprofen or loxoprofen was applied over the affected knee. Gait was assessed at 2, 4 and 6 h after application of the patch. The PGE concentration in the synovial fluid was measured after the gait assessment.

Key Findings: Application of SFPP (0.125, 0.25, 0.5 or 1 mg/sheet) was followed by a decrease in the visual gait score at all the doses examined. In the case of the other two NSAID patches, only the ketoprofen patch (1 or 2 mg/sheet) and loxoprofen patch (5 mg/sheet) produced a decrease in the visual gait score. All of the NSAID patches decreased the PGE production in the synovial fluid.

Conclusions: These results suggest the potential usefulness of SFPP as an analgesic patch in patients with inflammatory joint pain.

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