Prediction of Microvascular Invasion in Hepatocellular Carcinoma: Preoperative Gd-EOB-DTPA-Dynamic Enhanced MRI and Histopathological Correlation

Overview

Journal Contrast Media Mol Imaging

Specialty Radiology

Date 2018 Apr 3

PMID 29606926

Citations 39

Authors

Mengqi Huang

Bing Liao

Ping Xu

Huasong Cai

Kun Huang

Zhi Dong

Ling Xu

Zhenpeng Peng

Yanji Luo

Keguo Zheng

Baogang Peng

Zi-Ping Li

Shi-Ting Feng

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the imaging features observed in preoperative Gd-EOB-DTPA-dynamic enhanced MRI and correlated with the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients.

Methods: 66 HCCs in 60 patients with preoperative Gd-EOB-DTPA-dynamic enhanced MRI were retrospectively analyzed. Features including tumor size, signal homogeneity, tumor capsule, tumor margin, peritumor enhancement during mid-arterial phase, peritumor hypointensity during hepatobiliary phase, signal intensity ratio on DWI and apparent diffusion coefficients (ADC), T1 relaxation times, and the reduction rate between pre- and postcontrast enhancement images were assessed. Correlation between these features and histopathological presence of MVI was analyzed to establish a prediction model.

Results: Histopathology confirmed that MVI were observed in 17 of 66 HCCs. Univariate analysis showed tumor size ( = 0.003), margin ( = 0.013), peritumor enhancement ( = 0.001), and hypointensity during hepatobiliary phase ( = 0.004) were associated with MVI. A multiple logistic regression model was established, which showed tumor size, margin, and peritumor enhancement were combined predictors for the presence of MVI ( = 0.1). of this prediction model was 0.353, and the sensitivity and specificity were 52.9% and 93.0%, respectively.

Conclusion: Large tumor size, irregular tumor margin, and peritumor enhancement in preoperative Gd-EOB-DTPA-dynamic enhanced MRI can predict the presence of MVI in HCC.

Citing Articles

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