Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 And/or Photodynamic Therapy

Overview

Journal Ann Dermatol

Specialty Dermatology

Date 2018 Apr 3

PMID 29606817

Authors

Min Soo Jang

Ji Yun Jang

Jong Bin Park

Dong Young Kang

Jin Woo Lee

Taek Geun Lee

Hyun Hwangbo

Kee Suck Suh

Affiliations

Soon will be listed here.

Abstract

Background: Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) that is characterized clinically by variable types of skin eruptions, including plaques, acneiform lesions, and alopecic patches. Histopathologically, FMF is characterized by folliculotropic infiltrates.

Objective: This study was conducted to scrutinize the clinical and histopathologic features of FMF in Koreans and the responses to phototherapy.

Methods: Twenty Koreans diagnosed with MF who had histopathologic evidence of folliculotropism were enrolled.

Results: Eighteen patients had head-and-neck-region infiltration, while five had solitary lesion. In all patients, the atypical lymphocytic infiltrate had a perifollicular distribution. Twelve patients were treated with ultraviolet A (UVA)-1. Eleven of these 12 patients with early-stage FMF experienced >80% improvement (8: complete remission; 3: partial remission). Four patients, including 2 who relapsed after UVA-1, were treated with photodynamic therapy (PDT), reaching complete remission after PDT.

Conclusion: As FMF has variable clinical presentations, skin biopsy is required to confirm the diagnosis. And both UVA-1 and methyl aminolevulinate-PDT are clinically effective in treatment of early-stage FMF.

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