Liver Regeneration in the Acute Liver Failure Patient

Overview

Journal Clin Liver Dis

Specialty Gastroenterology

Date 2018 Apr 2

PMID 29605066

Citations 10

Authors

Keith M Wirth

Scott Kizy

Clifford J Steer

Affiliations

Soon will be listed here.

Abstract

Liver regeneration after simple resection represents a unique process in which the organ returns to its original size and histologic structure. Over the past 30 years, there has been significant progress in elucidating the mechanisms associated with regeneration after loss of hepatic mass. Liver regeneration after acute liver failure shares several of these classical pathways. It differs, however, in key processes, including the role of both differentiated and stemlike cells. This article outlines these differences in addition to new molecular mechanisms, including immunomodulation, microRNAs, and the gut-liver axis. In addition, applications to the patient population, including prognostication and stem cell therapies, are explored.

Citing Articles

CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.

Dou Z, Lu F, Hu J, Li B, Li X Sci Rep. 2024; 14(1):11008.

PMID: 38744845 PMC: 11094083. DOI: 10.1038/s41598-024-58248-8.

Exploring the roles of non-coding RNAs in liver regeneration.

Li P, Ma X, Huang D, Gu X Noncoding RNA Res. 2024; 9(3):945-953.

PMID: 38680418 PMC: 11046251. DOI: 10.1016/j.ncrna.2024.04.003.

Microbial influence on liver regeneration: understanding gut microbiota and hepatic recovery post partial hepatectomy.

Sharma S, Suk K Hepatobiliary Surg Nutr. 2024; 13(2):314-316.

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Integrated analysis of lncRNA/circRNA-miRNA-mRNA in the proliferative phase of liver regeneration in mice with liver fibrosis.

Wang Q, Long Z, Zhu F, Li H, Xiang Z, Liang H BMC Genomics. 2023; 24(1):417.

PMID: 37488484 PMC: 10364436. DOI: 10.1186/s12864-023-09478-z.

MicroRNA-122-functionalized DNA tetrahedron stimulate hepatic differentiation of human mesenchymal stem cells for acute liver failure therapy.

Wei H, Li F, Xue T, Wang H, Ju E, Li M Bioact Mater. 2023; 28:50-60.

PMID: 37214257 PMC: 10199164. DOI: 10.1016/j.bioactmat.2023.04.024.

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