Dementia and Vagotomy in Taiwan: a Population-based Cohort Study

Overview

Journal BMJ Open

Specialty General Medicine

Date 2018 Apr 1

PMID 29602843

Citations 9

Authors

Shih-Yi Lin

Cheng-Li Lin

I-Kuan Wang

Cheng-Chieh Lin

Chih-Hsueh Lin

Wu-Huei Hsu

Chia-Hung Kao

Affiliations

Soon will be listed here.

Abstract

Objective: Truncal vagotomy is associated with a decreased risk of subsequent Parkinson disease (PD), although the effect of vagotomy on dementia is unclear. In response, we investigated the risk of dementia in patients who underwent vagotomy.

Setting: Population-based cohort study.

Participants: A total of 155 944 patients who underwent vagotomy (vagotomy cohort) and 155 944 age-matched, sex-matched and comorbidity-matched controls (non-vagotomy cohort) were identified between 2000 and 2011.

Primary And Secondary Outcome Measures: All patient data were tracked until the diagnosis of dementia, death or the end of 2011. The cumulative incidence of subsequent dementia and HRs were calculated.

Results: The mean ages of the study patients in the vagotomy and non-vagotomy cohorts were 56.6±17.4 and 56.7±17.3 years, respectively. The overall incidence density rate for dementia was similar in the vagotomy and non-vagotomy cohorts (2.43 and 2.84 per 1000 person-years, respectively). After adjustment for age, sex and comorbidities such as diabetes, hypertension, hyperlipidaemia, stroke, depression, coronary artery disease and PD, the patients in the vagotomy cohort were determined to not be at a higher risk of dementia than those in the non-vagotomy cohort (adjusted HR=1.09, 95% CI 0.87 to 1.36). Moreover, the patients who underwent truncal vagotomy were not associated with risk of dementia (adjusted HR=1.04, 95% CI 0.87 to 1.25), compared with the patients who did not undergo vagotomy.

Conclusion: Vagotomy, either truncal or selective, is not associated with risk of dementia.

Citing Articles

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The gut-brain axis and cognitive control: A role for the vagus nerve.

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Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases.

Han Y, Wang B, Gao H, He C, Hua R, Liang C J Inflamm Res. 2022; 15:6213-6230.

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References

Brenner S . Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-L-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer's disease and.... Med Hypotheses. 2012; 80(1):103. DOI: 10.1016/j.mehy.2012.10.010. View

Kelly J . Structural biology: proteins downhill all the way. Nature. 2006; 442(7100):255-6. DOI: 10.1038/442255a. View

Aliev G, Smith M, Obrenovich M, de la Torre J, Perry G . Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotox Res. 2004; 5(7):491-504. DOI: 10.1007/BF03033159. View

Chi N, Chien L, Ku H, Hu C, Chiou H . Alzheimer disease and risk of stroke: a population-based cohort study. Neurology. 2013; 80(8):705-11. DOI: 10.1212/WNL.0b013e31828250af. View

Thal D, Capetillo-Zarate E, Del Tredici K, Braak H . The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ. 2006; 2006(6):re1. DOI: 10.1126/sageke.2006.6.re1. View

McLean C, Cherny R, Fraser F, Fuller S, Smith M, Beyreuther K . Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol. 1999; 46(6):860-6. DOI: 10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m. View

Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R . Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One. 2010; 5(1):e8762. PMC: 2808242. DOI: 10.1371/journal.pone.0008762. View

Bachhuber T, Katzmarski N, McCarter J, Loreth D, Tahirovic S, Kamp F . Inhibition of amyloid-β plaque formation by α-synuclein. Nat Med. 2015; 21(7):802-7. DOI: 10.1038/nm.3885. View

Cryan J, Dinan T . Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012; 13(10):701-12. DOI: 10.1038/nrn3346. View

10.

Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, OSullivan G, Pal A . Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep. 2012; 2:898. PMC: 3510466. DOI: 10.1038/srep00898. View

11.

Spillantini M, Murrell J, Goedert M, Farlow M, Klug A, Ghetti B . Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci U S A. 1998; 95(13):7737-41. PMC: 22742. DOI: 10.1073/pnas.95.13.7737. View

12.

Chen Y, Su J, Tseng C, Chen C, Lin C, Kao C . Inflammatory bowel disease on the risk of acute pancreatitis: A population-based cohort study. J Gastroenterol Hepatol. 2015; 31(4):782-7. DOI: 10.1111/jgh.13171. View

13.

Johnston D, Wilkinson A . Highly selective vagotomy without a drainage procedure in the treatment of duodenal ulcer. Br J Surg. 1970; 57(4):289-96. DOI: 10.1002/bjs.1800570414. View

14.

Lin M, Beal M . Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006; 443(7113):787-95. DOI: 10.1038/nature05292. View

15.

Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A . Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science. 2000; 287(5456):1265-9. DOI: 10.1126/science.287.5456.1265. View

16.

Knowles T, Vendruscolo M, Dobson C . The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol. 2014; 15(6):384-96. DOI: 10.1038/nrm3810. View

17.

Schwartz K, Boles B . Microbial amyloids--functions and interactions within the host. Curr Opin Microbiol. 2013; 16(1):93-9. PMC: 3622111. DOI: 10.1016/j.mib.2012.12.001. View

18.

Dubois B, Feldman H, Jacova C, DeKosky S, Barberger-Gateau P, Cummings J . Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007; 6(8):734-46. DOI: 10.1016/S1474-4422(07)70178-3. View

19.

Borovikova L, Ivanova S, Zhang M, Yang H, Botchkina G, Watkins L . Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000; 405(6785):458-62. DOI: 10.1038/35013070. View

20.

Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri C . The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013; 9(1):63-75.e2. DOI: 10.1016/j.jalz.2012.11.007. View