Effect of Phenylephrine on Static and Dynamic Accommodation

Overview

Journal J Optom

Specialty Ophthalmology

Date 2018 Apr 1

PMID 29602687

Citations 5

Authors

Antonio J Del Aguila-Carrasco

Francisco Lara

Paula Bernal-Molina

Resurreccion Riquelme-Nicolas

Ivan Marin-Franch

Jose J Esteve-Taboada

Robert Montes-Mico

Philip B Kruger

Norberto Lopez-Gil

Affiliations

Soon will be listed here.

Abstract

Purpose: We tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics.

Methods: We performed two experiments to test the effects of PHCl on static and on dynamic accommodation in 8 and 6 subjects, respectively. Objective wavefront measurements were recorded of the static accommodation response to a stimulus at different distances or dynamic accommodation response to a sinusoidally moving stimulus (between 1 and 3 D of accommodative demand at 0.2Hz). The responses were characterized using two methods: one that takes into account the mydriatic optical effects on the accommodation produced by higher-order aberrations of the eye and another that takes into account only power changes paraxially due to the action of the ciliary muscle and regardless of the pupil size.

Results: When mydriatic optical effects were taken into account, differences in responses before and after PHCl instillation were 0.51±0.53 D, and 0.12±0.15, for static and dynamic accommodation, respectively, and were statistically significant (p<0.039). When mydriatic optical effects were not taken into account, the differences in responses before and after PHCl instillation were -0.20±0.51 D, and -0.05±0.14, for static and dynamic accommodation, respectively, and were not statistically significant (p>0.313).

Conclusions: The mydriatic effect of the PHCl causes optical changes in the eye that can reduce the objective and subjective measurement of accommodation.

Citing Articles

Statistical Model of Ocular Wavefronts With Accommodation.

Mecho-Garcia M, Arcas-Carbonell M, Orduna-Hospital E, Sanchez-Cano A, Lopez-Gil N, Macedo-de-Araujo R Invest Ophthalmol Vis Sci. 2024; 65(12):12.

PMID: 39377736 PMC: 11463707. DOI: 10.1167/iovs.65.12.12.

Predictability of sinusoidally moving stimuli does not improve the accuracy of the accommodative response.

Del Aguila-Carrasco A, Marin-Franch I Sci Rep. 2021; 11(1):15195.

PMID: 34312461 PMC: 8313575. DOI: 10.1038/s41598-021-94642-2.

Anterior Segment Biometry During Accommodation and Effects of Cycloplegics by Swept-Source Optical Coherence Tomography.

Mitsukawa T, Suzuki Y, Momota Y, Suzuki S, Yamada M Clin Ophthalmol. 2020; 14:1237-1243.

PMID: 32440090 PMC: 7213076. DOI: 10.2147/OPTH.S252474.

Anterior Segment Biometry with Phenylephrine and Tropicamide during Accommodation Imaged with Ultralong Scan Depth Optical Coherence Tomography.

Zhang J, Ni Y, Li P, Sun W, Liu M, Guo D J Ophthalmol. 2019; 2019:6827215.

PMID: 30944731 PMC: 6421770. DOI: 10.1155/2019/6827215.

Optometry: a discipline and profession that feeds from and empowers other specialties.

Gonzalez-Meijome J J Optom. 2018; 12(1):1-2.

PMID: 30591145 PMC: 6318551. DOI: 10.1016/j.optom.2018.11.001.

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