Design of Hydrogels to Stabilize and Enhance Bone Morphogenetic Protein Activity by Heparin Mimetics

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2018 Mar 30

PMID 29597024

Citations 24

Authors

Soyon Kim

Zhong-Kai Cui

Paul Jay Kim

Lawrence Young Jung

Min Lee

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: Although bone morphogenetic protein-2 (BMP-2) is believed to be the most potent cytokine for bone regeneration, its clinical applications require supraphysiological BMP dosage due to its intrinsic instability and fast enzymatic degradation, leading to worrisome side effects. This study demonstrates a novel hydrogel platform that mimics a natural protector of BMPs, heparin, to sequester and stabilize BMP-2 for increased osteoinductive signaling. This study will achieve the stabilization of BMPs with prolonged bioactivity by a synthetic heparin mimic that has not been examined previously. Moreover, the heparin mimetic hydrogel surface can augment endogenous BMP activity by sequestering and localizing the cell-produced BMPs. The additional knowledge gained from this study may suggest basis for future development of material-based therapeutics for tissue engineering.

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