FePO Embedded in Nanofibers Consisting of Amorphous Carbon and Reduced Graphene Oxide As an Enzyme Mimetic for Monitoring Superoxide Anions Released by Living Cells

Overview

Journal Mikrochim Acta

Specialties Biotechnology
Chemistry

Date 2018 Mar 30

PMID 29594540

Citations 9

Authors

Ying Wang

Min-Qiang Wang

Ling-Li Lei

Zhao-Yang Chen

Ying-Shuai Liu

Shu-Juan Bao

Affiliations

Soon will be listed here.

Abstract

FePO is biocompatible and can act as a kind of promising enzyme mimetic. Unfortunately, the electrical conductivity of FePO is poor. In order to enhance its conductivity, FePO was embedded into nanofibers consisting of amorphous carbon and reduced graphene oxide (rGO) by an electrospinning technique. As a sensing material for monitoring superoxide anion (O) and typically operated at 0.5 V (vs. SCE), it displays high sensitivity (9.6 μA⋅μM⋅cm), a low detection limit (9.7 nM at S/N = 3), a wide linear response range (10 nM to 10 μM), and fast response (1.6 s). Due to its low detection limit and fast response, the sensor in our perception has a large potential for detecting superoxide anions released by HeLa cancer cells. Graphical abstract Schematic of the microstructure of FePO/C and FePO/rGO-C nanofibers, a photograph of cancer cells (HeLa), and the electrochemical response towards O of the sensor.

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