The Distributions of Voltage-Gated K Current Subtypes in Different Cell Sizes from Adult Mouse Dorsal Root Ganglia

Overview

Journal J Membr Biol

Date 2018 Mar 30

PMID 29594433

Citations 1

Authors

Anqi Sheng

Jiangru Hong

Lulu Zhang

Yan Zhang

Guangqin Zhang

Affiliations

Soon will be listed here.

Abstract

Voltage-gated K (K) currents play a crucial role in regulating pain by controlling neuronal excitability, and are divided into transient A-type currents (I) and delayed rectifier currents (I). The dorsal root ganglion (DRG) neurons are heterogeneous and the subtypes of K currents display different levels in distinct cell sizes. To observe correlations of the subtypes of K currents with DRG cell sizes, K currents were recorded by whole-cell patch clamp in freshly isolated mouse DRG neurons. Results showed that I occupied a high proportion in K currents in medium- and large-diameter DRG neurons, whereas I possessed a larger proportion of K currents in small-diameter DRG neurons. A lower correlation was found between the proportion of I or I in K currents and cell sizes. These data suggest that I channels are mainly expressed in medium and large cells and I channels are predominantly expressed in small cells.

Citing Articles

[Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain].

Zhu S, Liu D, Hu W, Yang H Nan Fang Yi Ke Da Xue Xue Bao. 2019; 39(9):1078-1082.

PMID: 31640967 PMC: 6881743. DOI: 10.12122/j.issn.1673-4254.2019.09.12.

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