Precision Light for the Treatment of Psychiatric Disorders

Overview

Journal Neural Plast

Specialty Neurology

Date 2018 Mar 30

PMID 29593784

Citations 12

Authors

Sevag Kaladchibachi

Fabian Fernandez

Affiliations

Soon will be listed here.

Abstract

Circadian timekeeping can be reset by brief flashes of light using stimulation protocols thousands of times shorter than those previously assumed to be necessary for traditional phototherapy. These observations point to a future where flexible architectures of nanosecond-, microsecond-, and millisecond-scale light pulses are compiled to reprogram the brain's internal clock when it has been altered by psychiatric illness or advanced age. In the current review, we present a chronology of seminal experiments that established the synchronizing influence of light on the human circadian system and the efficacy of prolonged bright-light exposure for reducing symptoms associated with seasonal affective disorder. We conclude with a discussion of the different ways that precision flashes could be parlayed during sleep to effect neuroadaptive changes in brain function. This article is a contribution to a special issue on curated by editors Shimon Amir, Karen Gamble, Oliver Stork, and Harry Pantazopoulos.

Citing Articles

Goncharova N, Chigarova O, Oganyan T Front Endocrinol (Lausanne). 2023; 13:1051882.

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The Importance of Early Identification for Parkinson's Disease Patients with Postural Instability and Gait Disturbance.

Wu Y, Yang Y, Gu S, Zhang Y, Shi R, Wang C Comput Intell Neurosci. 2022; 2022:6701519.

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Sleep Deprivation Does Not Influence Photic Resetting of Circadian Activity Rhythms in Drosophila.

Negelspach D, Kaladchibachi S, Dollish H, Fernandez F Clocks Sleep. 2022; 4(1):202-207.

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Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.

Lee R, McGee A, Fernandez F Neuropsychopharmacology. 2021; 47(4):866-879.

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Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules.

Gisabella B, Babu J, Valeri J, Rexrode L, Pantazopoulos H Front Neurosci. 2021; 15:646678.

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