Alternative Splicing of FOXP3-Virtue and Vice

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Mar 30

PMID 29593749

Citations 36

Authors

Reiner K W Mailer

Affiliations

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Abstract

FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.

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