Deconstructing the Pluripotency Gene Regulatory Network

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2018 Mar 30

PMID 29593328

Citations 55

Authors

Mo Li

Juan Carlos Izpisua Belmonte

Affiliations

Soon will be listed here.

Abstract

Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.

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