Lung Topology Characteristics in Patients with Chronic Obstructive Pulmonary Disease

Overview

Journal Sci Rep

Specialty Science

Date 2018 Mar 30

PMID 29593257

Citations 11

Authors

Francisco Belchi

Mariam Pirashvili

Joy Conway

Michael Bennett

Ratko Djukanovic

Jacek Brodzki

Affiliations

Soon will be listed here.

Abstract

Quantitative features that can currently be obtained from medical imaging do not provide a complete picture of Chronic Obstructive Pulmonary Disease (COPD). In this paper, we introduce a novel analytical tool based on persistent homology that extracts quantitative features from chest CT scans to describe the geometric structure of the airways inside the lungs. We show that these new radiomic features stratify COPD patients in agreement with the GOLD guidelines for COPD and can distinguish between inspiratory and expiratory scans. These CT measurements are very different to those currently in use and we demonstrate that they convey significant medical information. The results of this study are a proof of concept that topological methods can enhance the standard methodology to create a finer classification of COPD and increase the possibilities of more personalized treatment.

Citing Articles

A new computational framework for simulating airway resistance, fraction of exhaled nitric oxide, and diffusing capacity for nitric oxide.

Haut B, Karamaoun C, Rigaut C PLoS One. 2025; 20(1):e0311667.

PMID: 39883668 PMC: 11781630. DOI: 10.1371/journal.pone.0311667.

A topological classifier to characterize brain states: When shape matters more than variance.

Ferra A, Cecchini G, Nobbe Fisas F, Casacuberta C, Cos I PLoS One. 2023; 18(10):e0292049.

PMID: 37782651 PMC: 10545107. DOI: 10.1371/journal.pone.0292049.

The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia.

Chulian S, Stolz B, Martinez-Rubio A, Blazquez Goni C, Rodriguez Gutierrez J, Caballero Velazquez T PLoS Comput Biol. 2023; 19(8):e1011329.

PMID: 37578973 PMC: 10468039. DOI: 10.1371/journal.pcbi.1011329.

Persistent homology analysis distinguishes pathological bone microstructure in non-linear microscopy images.

Pritchard Y, Sharma A, Clarkin C, Ogden H, Mahajan S, Sanchez-Garcia R Sci Rep. 2023; 13(1):2522.

PMID: 36781895 PMC: 9925777. DOI: 10.1038/s41598-023-28985-3.

Multiscale topology characterizes dynamic tumor vascular networks.

Stolz B, Kaeppler J, Markelc B, Braun F, Lipsmeier F, Muschel R Sci Adv. 2022; 8(23):eabm2456.

PMID: 35687679 PMC: 9187234. DOI: 10.1126/sciadv.abm2456.

References

Xie X, de Jong P, Oudkerk M, Wang Y, Ten Hacken N, Miao J . Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis. Eur Radiol. 2012; 22(10):2085-93. PMC: 3431473. DOI: 10.1007/s00330-012-2480-8. View

Mohamed Hoesein F, de Hoop B, Zanen P, Gietema H, Kruitwagen C, van Ginneken B . CT-quantified emphysema in male heavy smokers: association with lung function decline. Thorax. 2011; 66(9):782-7. DOI: 10.1136/thx.2010.145995. View

Kovacev-Nikolic V, Bubenik P, Nikolic D, Heo G . Using persistent homology and dynamical distances to analyze protein binding. Stat Appl Genet Mol Biol. 2016; 15(1):19-38. DOI: 10.1515/sagmb-2015-0057. View

Sayiner A, Hague C, Ajlan A, Leipsic J, Wierenga L, Krowchuk N . Bronchiolitis in young female smokers. Respir Med. 2013; 107(5):732-8. DOI: 10.1016/j.rmed.2012.12.023. View

Chen Y, Ding M, Guan W, Wang W, Luo W, Zhong C . Validation of human small airway measurements using endobronchial optical coherence tomography. Respir Med. 2015; 109(11):1446-53. DOI: 10.1016/j.rmed.2015.09.006. View

Jones P . Health status and the spiral of decline. COPD. 2009; 6(1):59-63. DOI: 10.1080/15412550802587943. View

Delude C . Deep phenotyping: The details of disease. Nature. 2015; 527(7576):S14-5. DOI: 10.1038/527S14a. View

Kirby M, Yin Y, Tschirren J, Tan W, Leipsic J, Hague C . A Novel Method of Estimating Small Airway Disease Using Inspiratory-to-Expiratory Computed Tomography. Respiration. 2017; 94(4):336-345. DOI: 10.1159/000478865. View

ODonnell R, Peebles C, Ward J, Daraker A, Angco G, Broberg P . Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax. 2004; 59(10):837-42. PMC: 1746844. DOI: 10.1136/thx.2003.019349. View

10.

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V . Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380(9859):2095-128. PMC: 10790329. DOI: 10.1016/S0140-6736(12)61728-0. View

11.

Robins V, Wood P, Sheppard A . Theory and Algorithms for Constructing Discrete Morse Complexes from Grayscale Digital Images. IEEE Trans Pattern Anal Mach Intell. 2011; 33(8):1646-58. DOI: 10.1109/TPAMI.2011.95. View

12.

Mathers C, Loncar D . Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006; 3(11):e442. PMC: 1664601. DOI: 10.1371/journal.pmed.0030442. View

13.

Bendich P, Marron J, Miller E, Pieloch A, Skwerer S . Persistent Homology Analysis of Brain Artery Trees. Ann Appl Stat. 2016; 10(1):198-218. PMC: 5026243. DOI: 10.1214/15-AOAS886. View

14.

Chan J, Carlsson G, Rabadan R . Topology of viral evolution. Proc Natl Acad Sci U S A. 2013; 110(46):18566-71. PMC: 3831954. DOI: 10.1073/pnas.1313480110. View

15.

Coxson H, Leipsic J, Parraga G, Sin D . Using pulmonary imaging to move chronic obstructive pulmonary disease beyond FEV1. Am J Respir Crit Care Med. 2014; 190(2):135-44. DOI: 10.1164/rccm.201402-0256PP. View

16.

Galban C, Han M, Boes J, Chughtai K, Meyer C, Johnson T . Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med. 2012; 18(11):1711-5. PMC: 3493851. DOI: 10.1038/nm.2971. View

17.

Sieren J, Newell Jr J, Barr R, Bleecker E, Burnette N, Carretta E . SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs. Am J Respir Crit Care Med. 2016; 194(7):794-806. PMC: 5074650. DOI: 10.1164/rccm.201506-1208PP. View

18.

de Jong P, Muller N, Pare P, Coxson H . Computed tomographic imaging of the airways: relationship to structure and function. Eur Respir J. 2005; 26(1):140-52. DOI: 10.1183/09031936.05.00007105. View

19.

Coxson H . Quantitative computed tomography assessment of airway wall dimensions: current status and potential applications for phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008; 5(9):940-5. PMC: 2720108. DOI: 10.1513/pats.200806-057QC. View

20.

Nagatani Y, Murata K, Takahashi M, Nitta N, Nakano Y, Sonoda A . A new quantitative index of lobar air trapping in chronic obstructive pulmonary disease (COPD): comparison with conventional methods. Eur J Radiol. 2015; 84(5):963-74. DOI: 10.1016/j.ejrad.2014.12.018. View