Powdered Black Cumin Seeds Strongly Improves Serum Lipids, Atherogenic Index of Plasma and Modulates Anthropometric Features in Patients with Hashimoto's Thyroiditis

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2018 Mar 29

PMID 29587770

Citations 10

Authors

Mahdieh Abbasalizad Farhangi

Parvin Dehghan

Siroos Tajmiri

Affiliations

Soon will be listed here.

Abstract

Background: Hashimoto's thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto's thyroiditis.

Methods: Forty patients with Hashimoto's thyroiditis, aged between 22 and 50 years old, participated in the trial and were randomly allocated into two groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks. Serum lipids, glucose homeostasis, and anthropometric variables were evaluated at baseline and after intervention.

Results: Treatment with Nigella sativa significantly reduced body weight and body mass index (BMI). Serum concentrations of low density lipoprotein cholesterol (LDL) and triglyceride (TG) also decreased in Nigella sativa-treated group after 8 weeks; while serum high density lipoprotein cholesterol (HDL) significantly increased after treatment with Nigella sativa (P < 0.05). None of these changes had been observed in placebo treated group. Serum Nesfatin-1 concentrations was in inverse relationship with serum triglyceride (TG) (r = - 0.31, P = 0.04).

Conclusions: Giving attention to the potent beneficial effects of powdered black cumin seeds in improving serum lipid profile and anthropometric features in patients with Hashimoto's thyroiditis, this medicinal plant could be considered as a beneficial herbal supplement alongside with the disease- specific medications including Levothyroxine in management of Hashimoto's thyroiditis- related metabolic abnormalities.

Trial Registration: Iranian registry of clinical trials (registration number IRCT2014090819082N2 - Registered 2014-09-29).

Citing Articles

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Han M, Wu H, Yang W, Chen J BMC Endocr Disord. 2022; 22(1):173.

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References

Bamosa A, Kaatabi H, Lebdaa F, Elq A, Al-Sultanb A . Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol. 2011; 54(4):344-54. View

Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M . A systematic review of anti-obesity medicinal plants - an update. J Diabetes Metab Disord. 2013; 12(1):28. PMC: 3914705. DOI: 10.1186/2251-6581-12-28. View

Klein I, Danzi S . Thyroid disease and the heart. Circulation. 2007; 116(15):1725-35. DOI: 10.1161/CIRCULATIONAHA.106.678326. View

Kelishadi R, Ardalan G, Gheiratmand R, Gouya M, Mohammad Razaghi E, Delavari A . Association of physical activity and dietary behaviours in relation to the body mass index in a national sample of Iranian children and adolescents: CASPIAN Study. Bull World Health Organ. 2007; 85(1):19-26. PMC: 2636217. DOI: 10.2471/blt.06.030783. View

Datau E, Wardhana , Surachmanto E, Pandelaki K, Langi J, Fias . Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med Indones. 2010; 42(3):130-4. View

Kontiainen S, Schlenzka A, Koskimies S, Rilva A, Maenpaa J . Autoantibodies and autoimmune diseases in young diabetics. Diabetes Res. 1990; 13(4):151-6. View

Panebianco P, Rosso D, Destro G, Scarpinato R, Tropea S, Rizzo A . Use of disphosphonates in the treatment of osteoporosis in thyroidectomized patients on levothyroxin replacement therapy. Arch Gerontol Geriatr. 2008; 25(2):219-25. DOI: 10.1016/s0167-4943(97)00013-7. View

Farhangi M, Keshavarz S, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi A . The effect of vitamin A supplementation on thyroid function in premenopausal women. J Am Coll Nutr. 2013; 31(4):268-74. DOI: 10.1080/07315724.2012.10720431. View

Kanter M, Coskun O, Budancamanak M . Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol. 2006; 11(42):6684-8. PMC: 4355766. DOI: 10.3748/wjg.v11.i42.6684. View

10.

Farhangi M, Keshavarz S, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi A . White blood cell count in women: relation to inflammatory biomarkers, haematological profiles, visceral adiposity, and other cardiovascular risk factors. J Health Popul Nutr. 2013; 31(1):58-64. PMC: 3702359. DOI: 10.3329/jhpn.v31i1.14749. View

11.

Abdel-Sater K . Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol. 2011; 1(2):143-149. PMC: 3047244. View

12.

Farhangi M, Keshavarz S, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi A . Vitamin A supplementation, serum lipids, liver enzymes and C-reactive protein concentrations in obese women of reproductive age. Ann Clin Biochem. 2012; 50(Pt 1):25-30. DOI: 10.1258/acb.2012.012096. View

13.

Salem M . Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005; 5(13-14):1749-70. DOI: 10.1016/j.intimp.2005.06.008. View

14.

Kanter M, Coskun O, Korkmaz A, Oter S . Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. Anat Rec A Discov Mol Cell Evol Biol. 2004; 279(1):685-91. DOI: 10.1002/ar.a.20056. View

15.

Najmi A, Nasiruddin M, Khan R, Haque S . Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev Ctries. 2009; 28(1):11-4. PMC: 2772004. DOI: 10.4103/0973-3930.41980. View

16.

Wang C, Crapo L . The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin North Am. 1997; 26(1):189-218. DOI: 10.1016/s0889-8529(05)70240-1. View

17.

Su Y, Zhang J, Tang Y, Bi F, Liu J . The novel function of nesfatin-1: anti-hyperglycemia. Biochem Biophys Res Commun. 2009; 391(1):1039-42. DOI: 10.1016/j.bbrc.2009.12.014. View

18.

Farhangi M, Dehghan P, Tajmiri S, Mesgari Abbasi M . The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016; 16(1):471. PMC: 5112739. DOI: 10.1186/s12906-016-1432-2. View

19.

Sharifi N, Mahdavi R, Ebrahimi-Mameghani M . Perceived Barriers to Weight loss Programs for Overweight or Obese Women. Health Promot Perspect. 2014; 3(1):11-22. PMC: 3963684. DOI: 10.5681/hpp.2013.002. View

20.

Sokhanvar S, Khoshi A, Hajiaghaei S, Mousavinasab S, Golmohammadi Z . Association Between Apo Lipoprotein B Levels at Admission of Patients and Short-term Morbidity and Mortality After Myocardial Infarction. J Cardiovasc Thorac Res. 2013; 4(3):61-4. PMC: 3825361. DOI: 10.5681/jcvtr.2012.015. View