Colorectal Polyp Risk is Linked to an Elevated Level of Homocysteine

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Mar 28

PMID 29581245

Citations 6

Authors

Manchun Sun

Manyi Sun

Li Zhang

Songli Shi

Affiliations

Soon will be listed here.

Abstract

Several studies have reported an association between levels of folate, homocysteine, and vitamin B and the risk of colorectal polyps. Here, our aim is to examine the possible effect of folate, homocysteine, and vitamin B levels on the risk of colorectal polyps by means of meta-analysis based quantitative synthesis. According to our inclusion/exclusion criteria, a total of 13 case-control studies were enrolled. The -value of the association test, standard mean difference (SMD), and 95% confidence interval (CI) were calculated. Pooled analysis data showed a negative correlation between the risk of colorectal polyps and the levels of serum folate, red blood cell (RBC) folate, or vitamin B (all >0.05). Nevertheless, for homocysteine level, we also observed a statistically significant difference between cases and controls in the overall and subgroup analysis of hospital-based control (HB), population-based control (PB), Chinese, Caucasian, or Asian (all <0.05, SMD > 0). We found that increased levels of homocysteine may be statistically and significantly related to the risk of colorectal polyps.

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