Parabens and Measures of Adiposity Among Adults and Children from the U.S. General Population: NHANES 2007-2014

Overview

Journal Int J Hyg Environ Health

Specialties Environmental Health
Public Health

Date 2018 Mar 28

PMID 29580847

Citations 24

Authors

Lesliam Quiros-Alcala

Jessie P Buckley

Meleah Boyle

Affiliations

Soon will be listed here.

Abstract

Background: Emerging experimental studies suggest that parabens could affect metabolism by altering the microbiome or signaling pathways involved in adipocyte differentiation. While human exposure to parabens is widespread, epidemiologic studies assessing the role of these chemicals on adiposity measures are scarce.

Objective: We examined associations of parabens with adiposity measures among adults and children in the U.S. general population.

Methods: We conducted covariate-adjusted linear and logistic regression models to examine associations between urinary biomarker concentrations of four parabens (butyl-BP, ethyl-EP, methyl-MP, and propyl paraben-PP) and measures of adiposity (obesity; body mass index, BMI or BMI z-score; and waist circumference) among 4730 adults (2007-2014) and 1324 children (2007-2012), participating in the National Health and Nutrition Examination Survey. We also assessed heterogeneity of associations by gender.

Results: We generally observed significant inverse associations between adiposity measures and paraben biomarker concentrations among adults (BP, EP, MP, PP) and children (MP). For example, adjusted prevalence odds ratios (95% confidence intervals, CI) for obesity per a ten-fold increase in MP concentrations were 0.64 (95% CI: 0.55, 0.73) for adults and 0.71(95% CI: 0.52, 0.95) for children. Strength of inverse associations typically increased monotonically with increasing paraben exposure quartiles; and, in general, inverse associations were more pronounced among females. Associations remained when controlling for other phenolic compounds previously linked with adiposity measures.

Conclusions: In this cross-sectional study of adiposity measures and parabens, we observed consistent inverse associations in a representative sample of U.S adults and children. Further studies are warranted to confirm our findings, examine the potential role of paraben sequestration in adipose tissue, and elucidate mechanisms by which parabens could alter metabolism.

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References

Hu J, Raikhel V, Gopalakrishnan K, Fernandez-Hernandez H, Lambertini L, Manservisi F . Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model. Microbiome. 2016; 4(1):26. PMC: 4906585. DOI: 10.1186/s40168-016-0173-2. View

Ogden C, Carroll M, Kit B, Flegal K . Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014; 311(8):806-14. PMC: 4770258. DOI: 10.1001/jama.2014.732. View

Moos R, Angerer J, Dierkes G, Bruning T, Koch H . Metabolism and elimination of methyl, iso- and n-butyl paraben in human urine after single oral dosage. Arch Toxicol. 2015; 90(11):2699-2709. DOI: 10.1007/s00204-015-1636-0. View

Heindel J, Vom Saal F, Blumberg B, Bovolin P, Calamandrei G, Ceresini G . Parma consensus statement on metabolic disruptors. Environ Health. 2015; 14:54. PMC: 4473834. DOI: 10.1186/s12940-015-0042-7. View

Ley R, Turnbaugh P, Klein S, Gordon J . Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444(7122):1022-3. DOI: 10.1038/4441022a. View

Calafat A, Ye X, Wong L, Bishop A, Needham L . Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006. Environ Health Perspect. 2010; 118(5):679-85. PMC: 2866685. DOI: 10.1289/ehp.0901560. View

Torres-Fuentes C, Schellekens H, Dinan T, Cryan J . The microbiota-gut-brain axis in obesity. Lancet Gastroenterol Hepatol. 2017; 2(10):747-756. DOI: 10.1016/S2468-1253(17)30147-4. View

Shen J, Obin M, Zhao L . The gut microbiota, obesity and insulin resistance. Mol Aspects Med. 2012; 34(1):39-58. DOI: 10.1016/j.mam.2012.11.001. View

Dare S, Mackay D, Pell J . Relationship between smoking and obesity: a cross-sectional study of 499,504 middle-aged adults in the UK general population. PLoS One. 2015; 10(4):e0123579. PMC: 4401671. DOI: 10.1371/journal.pone.0123579. View

10.

Wolff M, Teitelbaum S, Pinney S, Windham G, Liao L, Biro F . Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ Health Perspect. 2010; 118(7):1039-46. PMC: 2920905. DOI: 10.1289/ehp.0901690. View

11.

Kang H, Kyung M, Ko A, Park J, Hwang M, Kwon J . Urinary concentrations of parabens and their association with demographic factors: A population-based cross-sectional study. Environ Res. 2016; 146:245-51. DOI: 10.1016/j.envres.2015.12.032. View

12.

Benowitz N, Bernert J, Caraballo R, Holiday D, Wang J . Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial/ethnic groups in the United States between 1999 and 2004. Am J Epidemiol. 2008; 169(2):236-48. DOI: 10.1093/aje/kwn301. View

13.

Buckley J, Herring A, Wolff M, Calafat A, Engel S . Prenatal exposure to environmental phenols and childhood fat mass in the Mount Sinai Children's Environmental Health Study. Environ Int. 2016; 91:350-6. PMC: 4834980. DOI: 10.1016/j.envint.2016.03.019. View

14.

Lankester J, Patel C, Cullen M, Ley C, Parsonnet J . Urinary triclosan is associated with elevated body mass index in NHANES. PLoS One. 2013; 8(11):e80057. PMC: 3836985. DOI: 10.1371/journal.pone.0080057. View

15.

Meeker J, Yang T, Ye X, Calafat A, Hauser R . Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage. Environ Health Perspect. 2010; 119(2):252-7. PMC: 3040614. DOI: 10.1289/ehp.1002238. View

16.

Hu P, Chen X, Whitener R, Boder E, Jones J, Porollo A . Effects of parabens on adipocyte differentiation. Toxicol Sci. 2012; 131(1):56-70. PMC: 3621350. DOI: 10.1093/toxsci/kfs262. View

17.

Perera F, Herbstman J . Prenatal environmental exposures, epigenetics, and disease. Reprod Toxicol. 2011; 31(3):363-73. PMC: 3171169. DOI: 10.1016/j.reprotox.2010.12.055. View

18.

Corbasson I, Hankinson S, Stanek 3rd E, Reeves K . Urinary bisphenol-A, phthalate metabolites and body composition in US adults, NHANES 1999-2006. Int J Environ Health Res. 2016; 26(5-6):606-17. DOI: 10.1080/09603123.2016.1233524. View

19.

Fuente-Martin E, Argente-Arizon P, Ros P, Argente J, Chowen J . Sex differences in adipose tissue: It is not only a question of quantity and distribution. Adipocyte. 2013; 2(3):128-34. PMC: 3756100. DOI: 10.4161/adip.24075. View

20.

Hu P, Kennedy R, Chen X, Zhang J, Shen C, Chen J . Differential effects on adiposity and serum marker of bone formation by post-weaning exposure to methylparaben and butylparaben. Environ Sci Pollut Res Int. 2016; 23(21):21957-21968. DOI: 10.1007/s11356-016-7452-0. View