Mesoscale Connectomics

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2018 Mar 27

PMID 29579713

Citations 36

Authors

Hongkui Zeng

Affiliations

Soon will be listed here.

Abstract

Brain cells communicate with one another via local and long-range synaptic connections. Structural connectivity is the foundation for neural function. Brain-wide connectivity can be described at macroscopic, mesoscopic and microscopic levels. The mesoscale connectome represents connections between neuronal types across different brain regions. Building a mesoscale connectome requires a detailed understanding of the cell type composition of different brain regions and the patterns of inputs and outputs that each of these cell types receives and forms, respectively. In this review, I discuss historical and contemporary tracing techniques in both anterograde and retrograde directions to map the input and output connections at population and individual cell levels, as well as imaging and network analysis approaches to build mesoscale connectomes for mammalian brains.

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