Pauses in Cholinergic Interneuron Firing Exert an Inhibitory Control on Striatal Output in Vivo

Overview

Journal Elife

Specialty Biology

Date 2018 Mar 27

PMID 29578407

Citations 26

Authors

Stefano Zucca

Aya Zucca

Takashi Nakano

Sho Aoki

Jeffery Wickens

Affiliations

Soon will be listed here.

Abstract

The cholinergic interneurons (CINs) of the striatum are crucial for normal motor and behavioral functions of the basal ganglia. Striatal CINs exhibit tonic firing punctuated by distinct pauses. Pauses occur in response to motivationally significant events, but their function is unknown. Here we investigated the effects of pauses in CIN firing on spiny projection neurons (SPNs) - the output neurons of the striatum - using in vivo whole cell and juxtacellular recordings in mice. We found that optogenetically-induced pauses in CIN firing inhibited subthreshold membrane potential activity and decreased firing of SPNs. During pauses, SPN membrane potential fluctuations became more hyperpolarized and UP state durations became shorter. In addition, short-term plasticity of corticostriatal inputs was decreased during pauses. Our results indicate that, in vivo, the net effect of the pause in CIN firing on SPNs activity is inhibition and provide a novel mechanism for cholinergic control of striatal output.

Citing Articles

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