Targeted Deep Sequencing of CD34+ Cells from Peripheral Blood Can Reproduce Bone Marrow Molecular Profile in Myelodysplastic Syndromes

Overview

Journal Am J Hematol

Specialty Hematology

Date 2018 Mar 26

PMID 29575088

Citations 8

Authors

Roman Martin

Pamela Acha

Christina Ganster

Laura Palomo

Sascha Dierks

Francisco Fuster-Tormo

Mar Mallo

Vera Adema

Paula Gomez-Marzo

Nuri De Haro

Neus Solanes

Lurdes Zamora

Blanca Xicoy

Katayoon Shirneshan

Johanna Flach

Friederike Braulke

Julie Schanz

Arkadiusz Kominowski

Martin Stromburg

Alina Brockmann

Lorenz Trumper

Francesc Sole

Detlef Haase

Affiliations

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References

Mohamedali A, Gaken J, Ahmed M, Malik F, Smith A, Best S . High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS). Leukemia. 2015; 29(9):1928-38. DOI: 10.1038/leu.2015.110. View

Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, Van Loo P . Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013; 122(22):3616-27. PMC: 3837510. DOI: 10.1182/blood-2013-08-518886. View

Braulke F, Schanz J, Jung K, Shirneshan K, Schulte K, Schuetze C . FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: verification of the method and application to 27 MDS patients. Leuk Res. 2010; 34(10):1296-301. DOI: 10.1016/j.leukres.2010.01.010. View

Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G . Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia. 2013; 28(2):241-7. PMC: 3918868. DOI: 10.1038/leu.2013.336. View

Tefferi A, Lasho T, Patnaik M, Saeed L, Mudireddy M, Idossa D . Targeted next-generation sequencing in myelodysplastic syndromes and prognostic interaction between mutations and IPSS-R. Am J Hematol. 2017; 92(12):1311-1317. DOI: 10.1002/ajh.24901. View